High throughput screen

Details High throughput screen High throughput screen

2005-08-30

2005-08-30

Ponnaluri, Padmashri (Department: 1639)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C435S004000, C435S007200, C435S287100, C435S287200, C435S288500, C436S518000, C436S528000

Reexamination Certificate

active

06936462

ABSTRACT:
The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. More particularly it relates to a structure comprising a biological membrane adhered to a porous or perforated substrate, a biological membrane capable of adhering with high resistance seals to a substrate such as perforated glass and the ability to form sheets having predominantly an ion channel or transporter of interest, a high throughput screen for determining the effect of test compounds on ion channel or transporter activity, methods for manufacture of the structure, membrane and substrate, and a method for monitoring ion channel or transporter activity in a membrane.

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