High throughput multi-dimensional sample analysis

Details High throughput multi-dimensional sample analysis High throughput multi-dimensional sample analysis

2006-11-07

2006-11-07

Wells, Nikita (Department: 2881)

Radiant energy

Ionic separation or analysis

With sample supply means

C137S625460, C137S625470, C073S864830, C073S023420, C436S050000

Reexamination Certificate

active

07132650

ABSTRACT:
High throughput analytical systems and methods employing multiple liquid phase separation process regions coupled to a common mass spectrometer are provided. Disclosed systems and methods permits parallel separation and parallel storage of discrete eluate fractions, followed by sequential discharge and ionization of previously stored eluate portions to yield a composite ion stream containing the sequential series of eluate portions, followed by mass analysis of the ion stream. A common manifold may receive ions and utilize pressurized gas or ion gating to direct ions within the manifold toward the mass spectrometer inlet.

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Misharin, Alexander S. et al.,High-Throughput Mass Spectrometer Using Atmospheric Pressure Ionization and a Cylindrical Ion Trap Array, “Analytical Chemistry,” vol. 77, No. 2, Jan. 15, 2005, pp. 459-470.

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