Chemical apparatus and process disinfecting – deodorizing – preser – Control element responsive to a sensed operating condition
Patent
1998-08-10
2000-10-17
Le, Long V.
Chemical apparatus and process disinfecting, deodorizing, preser
Control element responsive to a sensed operating condition
422 63, 422 65, 436 43, 436 47, G01N 3502
Patent
active
061326852
ABSTRACT:
The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multiwell microtiter plates or other array structures. The multiwell plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multiwell plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.
REFERENCES:
patent: 4349275 (1982-09-01), Ayotte et al.
patent: 4675300 (1987-06-01), Zare et al.
patent: 4737464 (1988-04-01), McConnell et al.
patent: 4908112 (1990-03-01), Pace
patent: 4963498 (1990-10-01), Hillman et al.
patent: 4978503 (1990-12-01), Shanks et al.
patent: 5096807 (1992-03-01), Leaback
patent: 5122342 (1992-06-01), McCulloch et al.
patent: 5126022 (1992-06-01), Soane et al.
patent: 5140161 (1992-08-01), Hillman et al.
patent: 5144139 (1992-09-01), Hillman et al.
patent: 5164598 (1992-11-01), Hillman et al.
patent: 5171132 (1992-12-01), Miyazaki et al.
patent: 5171534 (1992-12-01), Smith et al.
patent: 5188963 (1993-02-01), Stapleton
patent: 5192405 (1993-03-01), Petersen et al.
patent: 5271724 (1993-12-01), van Lintel
patent: 5273718 (1993-12-01), Skold et al.
patent: 5277556 (1994-01-01), van Lintel
patent: 5278048 (1994-01-01), Parce et al.
patent: 5294795 (1994-03-01), Lehtinen et al.
patent: 5296375 (1994-03-01), Kricka et al.
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5324591 (1994-06-01), Georger, Jr. et al.
patent: 5375979 (1994-12-01), Trah
patent: 5380493 (1995-01-01), Chavez et al.
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5395503 (1995-03-01), Parce et al.
patent: 5427946 (1995-06-01), Kricka et al.
patent: 5429734 (1995-07-01), Gajar et al.
patent: 5445939 (1995-08-01), Anderson
patent: 5483843 (1996-01-01), Miller et al.
patent: 5486335 (1996-01-01), Wilding et al.
patent: 5496697 (1996-03-01), Parce et al.
patent: 5498392 (1996-03-01), Wilding et al.
patent: 5519635 (1996-05-01), Miyake et al.
patent: 5571410 (1996-11-01), Swedberg et al.
patent: 5585069 (1996-12-01), Zanzucchi et al.
patent: 5592289 (1997-01-01), Norris
patent: 5593838 (1997-01-01), Zanzucchi et al.
patent: 5605662 (1997-02-01), Heller et al.
patent: 5620894 (1997-04-01), Barger et al.
patent: 5637469 (1997-06-01), Wilding et al.
patent: 5650075 (1997-07-01), Haas et al.
patent: 5654200 (1997-08-01), Copeland et al.
patent: 5658723 (1997-08-01), Oberhardt
patent: 5773298 (1999-06-01), Lynggaard et al.
patent: 5780754 (1998-07-01), Karlberg et al.
patent: 5955028 (1999-09-01), Chow
patent: 5993746 (1999-11-01), Priha et al.
Bao et al., "Ultramicro enzyme assays in a capillary electroporetic system" J. Chromatog. (1992) 608:217-224.
Bunin et al., "A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives" (1992) J. Am. Chem. Soc. 114:10997-10998.
Cho et al., "An unnatural biopolymer" Science (1993) 261:1303-*1305.
Chu et al., "Affinity capillary electrophoresis-mass spectrometry for screening combinatorial libraries" J. Am. Chem. Soc. (1996) 118:7827-7835.
Dasgupta et al., "Electroosmosis: A reliable fluid propulsion system for flow injection analysis" Anal. Chem. (1994) 66:1792-1798.
Harmon et al., "Mathematical treatment of electrophoretically mediated microanalysis" Anal. Chem. (1993) 65:2655-2662.
Harmon et al., "Selectivity in electrophoretically medicated microanalysis by control of product detection time" Anal. Chem. (1994) 66:3797-3805.
Harrison et al., "Capillary electrophoresis and sample injection systems integrated on a planar glass chip" Anal. Chem. (1992) 64:1926-1932.
Harrison et al., Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip Science (1993) 261:895-897.
Jacobson et al., "Effects of injection schemes and column geometry on the performance of microchip electrophoresis devices" Anal. Chem. (1994) 66:1107-1113.
Jacobson et al., "High-speed separations on a microchip" Anal. Chem. (1994) 66:1114-1118.
Jacobson et al., "Open channel electrochromatography on a microchip" Anal. Chem. (1994) 66:2369-2373.
Jacobson et al., "Microchip electrophoresis with simple stacking" Electrophoresis (1995) 16:481-486.
Jacobson et al., "Fused quartz substrates for microchip electrophoresis" Anal. Chem. (1995) 67:2059-2063.
Jung et al., "Multiple peptide synthesis methods and their applications" Angew. Chem. Int. Ed. Engl. (1992) 31:367-383.
Kikuchi et al., "Optically accessible microchannels formed in a single-crystal silicon substrate for studies of blood rheology" Microvascular Res. (1992) 44:226-240.
Koutny et al., "Microchip electrophoretic immunoassay for serum cortisol" Anal. Chem. (1996) 68:18-22.
Linhares et al., "Use of an on-column fracture in capillary zone electrophoresis for sample introduction" Anal. Chem. (1991) 63:2076-2078.
Manz et al. "Miniaturized total chemical analysis systems: A novel concept for chemical sensing" Sensors and Actuators (1990) B1:244-248.
Manz et al. "Micromachining of monocrystalline silicon and glass for chemical analysis systems. A look into next century's technology or just a fashionable craze?" Trends in Anal. Chem. (1991) 10(5):144-148.
Manz et al. "Electroosmotic pumping and electrophoretic separations for miniaturized chemical analysis systems" J. Micromech. Microeng.(1994) 4:257-265.
Pavia et al., "The generation of molecular diversity" Bioorgan. Med. Chem. Lett. (1993) 3(3):387-396.
Ramsey et al. "Microfabricated chemical measurement systems" Nature Medicine (1995) 1 (10):1093-1096.
Schmalzing et al., "Solution-phase immunoassay for determination of cortisol in serum by capillary lectrophoresis" Clin. Chem. (1995) 41(9):1403-1406.
Seiler et al. "Planar glass chips for capillary electrophoresis: Repetitive sample injection, quantitation, and separation efficiency" Anal. Chem. (1993) 65:1481-1488.
Seller et al., "Electroosmotic pumping and valveless control of fluid flow within a manifold of capillaries on glass chip" Anal. Chem. (1994) 66:3485-3491.
Simon et al., "Peptoids: A modular approach to drug discovery" Proc. Natl. Acad. Sci. USA (1992) 89:9367-9371.
Song et al., "Multisample analysis using an array of microreactors for an alternatiin-current field-enhanced latex immunoassay" Anal. Chem. (1994) 66 (6):778-781.
Weaver et al., "Gel microdroplets: Rapid detection and enumeration of individual microorganisms by their metabolic activity" Bio/technology (1988) 6:1084-1089.
Wiley et al., "Peptidomimetics derived from natural products" Medicinal Research Reviews (1993) 13(3)327-384.
Wooley et al., "Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips" Proc. Natl. Acad. Sci. USA (1994) 91:11348-11352.
Zuckerman et al., "Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer sold-phase synthesis" J. Am. Chem. Soc. (1992) 114:10646-10647.
Chow Calvin Y. H.
Kercso Joseph E.
Parce J. Wallace
Sundberg Steven A.
Toth Andrew W.
Barrish, Esq. Mark D.
Caliper Technologies Corporation
Le Long V.
LandOfFree
High throughput microfluidic systems and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with High throughput microfluidic systems and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High throughput microfluidic systems and methods will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-465513