High-throughput glutathione S-transferase polymorphic allele...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S091200, C536S023500, C536S024310, C536S024330

Reexamination Certificate

active

07083923

ABSTRACT:
A high-throughput assay for characterizing a subject's genetic makeup is disclosed. Specifically a high-throughput assay utilizing PCR is disclosed that permits the rapid and accurate characterization of a subject's inherited alleles of the polymorphic glutathione S-transferase (GST) genes GSTM1, GSTM3, GSTP1, and GSTT1. This method allows detection of the specific alleles inherited, including the gene dosage of GSTM1 and GSTT1 while not requiring restriction endonuclease digestion of the PCR products in order to detect length differences. Further, the method allows all analyses to be performed simultaneously in the same gel lane, thus further adding efficiency and cost-effectiveness.

REFERENCES:
patent: 5888778 (1999-03-01), Shuber
patent: 5965363 (1999-10-01), Monforte et al.
patent: 19738908 (1999-03-01), None
Kristensen. Pharmacogentics. 1998. 8: 441-447.
Lucentini. The Scientist. Dec. 2004, p. 20.
Jourenkova-Mironova et al. International Journal of Cancer. 1999. 81: 44-48.
Matthias et al. Cancer Epidemiology, Biomarkers and Prevention. Sep. 1999. 8: 815-823.
“Enabling Large-Scale Pharmacogenetic Studies by High-Throughput Mutation Detection and Genotyping Technologies,” Michael M. Shi,Clinical Chemistry, pp. 164-172, 2001.
“High-Throughput Genotyping Method for Glutathione,”Research Communications in Molecular Pathology and Pharmacology, vol. 103, No. 1, Michael M. Shi, pp. 3-15.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

High-throughput glutathione S-transferase polymorphic allele... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with High-throughput glutathione S-transferase polymorphic allele..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High-throughput glutathione S-transferase polymorphic allele... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3650868

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.