High throughput genetic screening of lipid and cholesterol...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition

Reexamination Certificate

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C424S001110, C424S009100

Reexamination Certificate

active

07488467

ABSTRACT:
The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid processing; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism.

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Pack, M. et al., 1996, “Mutations affecting development of zebrafish digestive organs”, Development (Cambridge), 123(1):321-328.

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