Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-10-29
2000-11-07
Chin, Christopher L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
4352891, 4353051, 435 4, 435 75, 435 792, 435 793, 435 794, 435 795, 435 72, 436501, 436512, 436517, 436518, 436532, 436543, 436544, 436545, 436546, 436804, 436809, 436823, 530350, 530828, 530866, G01N 3353, G01N 33537, G01N 33534, C12Q 100, C07K 100
Patent
active
061435074
ABSTRACT:
Disclosed is a high throughput compatible assay that is useful for the identification of specific antagonists of TRAF-receptor interactions. The modular flexibility of the assay makes it possible to introduce simple modifications in order to measure the interaction of any TNF receptor cytoplasmic domain (or TRAF-binding protein) with any of the six TRAF proteins, TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6.
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Crute James J.
Kehry Marilyn R.
Pullen Steven S.
Boehringer Ingelheim Pharmaceuticals Inc.
Bottino Anthony P.
Chin Christopher L.
Do Pensee T.
Raymond Robert P.
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