High through-put cloning of protooncogenes

Details High through-put cloning of protooncogenes High through-put cloning of protooncogenes

2006-08-01

2006-08-01

Horlick, Kenneth R. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

C435S006120, C435S091200

Reexamination Certificate

active

07083913

ABSTRACT:
The present invention provides a process of identifying protooncogenes using high-throughput provirus tagging (HPT), e.g., by recovering host/virus junction sequences from chimeric transcripts containing both host and virus sequences.

REFERENCES:
patent: WO 02/057497 (2002-07-01), None
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A. Berns, et al., “Identification and Characterization of Collaborating Oncogenes in Compound Mutant Mice,” Cancer Research (Suppl.), 59, pp. 1773S-1777S (1999).
H. Jacobs, “TCR-Idepedent T Cell Development Mediated by Gain-Of-Oncogene Function or Loss-of-Tumor-Suppressor Gene Function,” Immunology, vol. 12, pp. 487-502 (2000).
H. Mikkers, et al., “High-Throughput Retroviral Tagging to Identify Components of Specific Signaling Pathways in Cancer,” Nature Genetics, vol. 32, pp. 153-159 (2002).
International Search Report mailed Feb. 6, 2003.
Maarten Van Lohuizen et al, Identification of Cooperation Oncogenes in Eμ-mycTransgenetic Mice by Provirus Tagging, Cell Magazine, May 31, 1991, 737-752, V 65, n 5, Cell Press, Cambridge, USA, (Duplicate).
Anton Berns et al, Identification and Characterization of Collabarationg Oncogenes in Compound Mutant Mice1, Cancer Research (Suppl.), Journal, Apr. 1, 1999, 1773s-1777s, v. 59, n 7 suppl, USA, (Duplicate).

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