High speed single electrode membrane voltage clamp

Details High speed single electrode membrane voltage clamp High speed single electrode membrane voltage clamp

1981-11-30

1984-04-10

Cohen, Lee S.

Surgery

Truss

Pad

A61B 504

Patent

active

044415079

ABSTRACT:
A high speed single electrode voltage clamp circuit for enabling study of the action potentials in small and otherwise inaccessible nerve cells. The circuit includes a high input impedance, low input capacity input stage, a high frequency emphasis equalization network, and separate low frequency and transient compensation networks and spectral modification circuitry. In addition, computer correction is utilized to eliminate transient errors. Proper operation of the clamp is also monitored by means of a computer.

REFERENCES:
patent: 4240443 (1980-12-01), Ionesco
Park et al., "Single Electrode Voltage Clamp . . . " J. of Neuroscience Methods, 3/81.
Johnston et al., "Voltage Clamp . . . Neurones", Nature, 7/80.
Kootsey et al., "Buffer Amplifier . . . ", IEEE Trans BME, Sep. 1973.
Wilson et al., "Voltage Clamping . . . Single Microelectrode", J. of Neurobiology, vol. 6, No. 4, pp. 411-422.
Merickel, "Design of Single Electrode Voltage Clamp", J. Neuroscience Method, 2/80, 87-96.
Jochem et al., "A High Voltage Electrometer . . . ", J. Neuroscience Methods 3/81, 261-269.
Zoble et al., "Automated On-Line . . . Curves", IEEE Trans. BioMed. Eng., vol. BME 25, No. 5, Sep. 1978, 481-483.

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