Radiant energy – Luminophor irradiation
Patent
1991-12-13
1993-05-18
Fields, Carolyn E.
Radiant energy
Luminophor irradiation
2504591, 356317, 356318, G01N 2164
Patent
active
052123863
ABSTRACT:
Apparatus for cross-correlation frequency domain fluorometry and/or phosphorimetry in which means are provided for sequentially performing runs of the cross correlation frequency domain fluorometry and/or phosphorimetry at sequentially differing first and second frequencies. The intensities of signal responses of the runs are detected at the respective cross-correlation frequency in each run. The detection of the signal response is prolonged in each run until an integrated signal with a specified standard deviation has been acquired at each of the differing runs. Preferably the sequential runs are automatically executed by a program. Also, the waveforms sensed by deriving the resultant signal response in each run are folded. That is: corresponding segments of the waveforms are superimposed to obtain an average waveform value for each run having an increased signal to noise ratio over the individual waveform segments. Also, preferably, a software-created variable frequency digital filter is used to filter signal responses at the cross-correlation frequency.
REFERENCES:
patent: 4840485 (1989-06-01), Gratton
patent: 4937457 (1990-06-01), Mitchell
Article by B. A. Feddersen et al. entitled Digital Parallel Acquisition in Frequency Domain Fluorimetry, Rev. Sci. Instrum. 60(9), Sep., 1989 pp. 2929-2936.
Article by Beniamino Barbieri et al. entitled Synthesizers' Phase Noise in Frequency-Domain Fluorometry, Rev. Sci. Instrum. 60(10), Oct., 1989, pp. 3201-3206.
Article by Brett Feddersen et al. entitled Direct Waveform Collection and Analysis of Phase Fluorometry Data, Biophysical Journal 53 (2) 404a (1988) consisting of 10 pages.
Article by Enrico Gratton et al. entitled A Continuously Variable Frequency Cross-Correlation Phase Fluorometer With Picosecond Resolution, Biophysical Journal, vol. 44, pp. 315-324 (1983).
Barbieri Beniamino
Gratton Enrico
Fields Carolyn E.
I.S.S. (U.S.A.) Inc.
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