High speed combination multi-mode ionization source for mass...

Details High speed combination multi-mode ionization source for mass... High speed combination multi-mode ionization source for mass...

2007-08-01

2010-10-26

Vanore, David A (Department: 2881)

Radiant energy

Ion generation

Methods

C250S282000, C250S283000, C250S286000, C250S287000, C250S288000, C250S42300F

Reexamination Certificate

active

07820980

ABSTRACT:
The present invention combines ionization modes produced by, for example, electrospray (ESI), atmospheric pressure chemical ionization (APCI), and thermospray for analysis of molecules. Specifically, this invention relates to the creation of a new source apparatus combining APCI and ESI which will interface with existing mass spectrometers, as well as the creation of new mass spectrometers where the present invention would be the ionization source. Furthermore, the present invention relates to an ionization source for a mass spectrometer which features an ion chamber defining an ion path, an electrospray probe for ionizing a sample using electrospray ionization, a corona discharge needle for ionizing a sample using atmospheric pressure chemical ionization, a power supply for applying an electrical potential to one of said electrospray probe and said corona discharge needle, and a solid state switch for directing the electrical potential from the power supply to one of the electrospray probe and said corona discharge needle.

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