Solid material comminution or disintegration – Processes – With application of fluid or lubricant material
Patent
1996-05-08
1998-02-24
Husar, John M.
Solid material comminution or disintegration
Processes
With application of fluid or lubricant material
241 22, 241 23, 241 33, 241 4617, 241 65, B02C 1900
Patent
active
057204390
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
This invention relates to a method for the production of granules in the field of medicines or foodstuffs and an apparatus therefor. More particularly, this invention relates to a method for obtaining granules containing components thereof in a highly homogeneous state by using a high speed agitated granulating machine and effecting the agitating, granulating, disintegrating, and drying operations simultaneously and an apparatus to be used therefor.
BACKGROUND ART
One of the methods available for wet production of granules is the method of high speed agitated granulation using a high speed agitated granulating machine. The "high speed agitated granulating machine" is a granulating device which is provided in the agitating vessel thereof with agitating blades for imparting a rolling and agitating action on a substance subjected to granulation and also with disintegrating blades for imparting a disintegrating action thereon. It is capable of obtaining heavy spherical particles by causing the substance subjected to granulation to be spirally circulated by means of the agitating blades, adding a binding liquid to the spiral stream of the substance and meanwhile granulating the resultant mixture and, at the same time, imparting powerful shearing force locally to the mass of granules in motion thereby disintegrating it.
By this granulating method, however, the homogeneity which the composition of components assumes during the course of mixing cannot be easily kept intact thence because the binding liquid is instantaneously added dropwise to the circulating stream of the substance for granulation and the substance in a consequent wetted state is pelletized and, as a result, the components of the substance are liable to succumb to migration. Specifically when the binding liquid is added dropwise to the substance, those of the particles which are amply coated with the binding liquid during the course of granulation form coarse lumps and those which are not amply coated therewith form fine particulates. In the case of finely divided active components which are not easily wetted with the binding liquid, once they are wetted, they are particularly liable to adhere to and aggregate on the coarse lumps and, as a result, induce the phenomenon of segregation of the components in the formed granules. Further, the fact that the substance is subjected to the granulation in its wetted state entails the disadvantage that this substance is liable to adhere to and aggregate on the inner wall of the agitating vessel or on the agitating blades to the extent of rendering production of uniform granules difficult.
The high speed agitated granulating machine mentioned above is known to embrace a version which is provided with a jacket. This jacket, however, has been solely utilized for thermally drying the granules still in process of formation subsequently to the granulating operation, cooling the substance of highly adhesive or thermally unstable quality during the course of granulation, or thermally fusing the binder which is made of a low melting material and put to use in a powdery form. A method which uses the jacket as a means for drying the substance undergoing the process of granulation and performs the agitating, granulating, drying, and disintegrating operations simultaneously and continuously has not been adopted to date. Nor has there existed any high speed agitated granulating machine which is provided with an electric control circuit for automatically performing these operations.
The other methods which are available for wet production of granules include a method of kneading granulation which resorts to a compaction type kneading device or a rolling and agitating kneading device and, when necessary, effects granulation by the use of an extruding pelletizer or a crushing pelletizer, a method of fluidized-bed granulation which aggregates and pelletizes a given substance as dispersed in the form of a fluidized bed, and a method of complex granulation which combines the method of fluidized-bed granulati
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Ohm K.K. Mar. 10, 1991 Japan Powder Industry Technology Association Granulation Handbook.
Moro Shoichi
Nakazawa Shinzo
Husar John M.
Tokyo Tanabe Company Limited
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