Induced nuclear reactions: processes – systems – and elements – Nuclear transmutation – By neutron bombardment
Reexamination Certificate
2003-11-20
2004-10-12
Keith, Jack (Department: 3641)
Induced nuclear reactions: processes, systems, and elements
Nuclear transmutation
By neutron bombardment
C424S001110, C424S001610
Reexamination Certificate
active
06804319
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to methods of preparing medically useful radioisotopes, particularly high specific activity radioisotopes, and more particularly to methods of preparing high specific activity platinum- 195m (
195m
Pt).
BACKGROUND OF THE INVENTION
There is broad interest, from dosimetric perspectives, on the use of Auger-emitting radioisotopes coupled to specific cellular
uclear targeting vectors for cancer therapy. The highest radiobiological effectiveness (RBI) results when Auger emitters are incorporated into the highly radiosensitive cell nucleus. Tumor cell-targeted agents radiolabeled with
195m
Pt could offer new opportunities for cancer therapy by high linear energy transfer (LET) Auger electrons, but
195m
Pt is not currently available in sufficiently high specific activity.
OBJECTS OF THE INVENTION
Accordingly, objects of the present invention include: provision of high specific activity platinum-195m (
195m
Pt), provision of a high specific activity Auger-emitting radioisotope for coupling to specific cellular
uclear targeting vectors for cancer therapy. Further and other objects of the present invention will become apparent from the description contained herein.
SUMMARY OF THE INVENTION
In accordance with one aspect of the present invention, the foregoing and other objects are achieved by a new composition of matter that includes
195m
Pt characterized by a specific activity of at least 30 mCi/mg Pt.
In accordance with another aspect of the present invention, high-specific-activity
195m
Pt, is made by a method that includes the steps of: exposing Irridium-193 (
193
Ir) to a flux of neutrons sufficient to convert a portion of the
193
Ir to
195m
Pt to form an irradiated material; dissolving the irradiated material to form an intermediate solution comprising Ir and Pt; and separating the Pt from the Ir by cation exchange chromatography to produce high specific activity
195m
Pt.
REFERENCES:
patent: 4414145 (1983-11-01), Panek
patent: 5862193 (1999-01-01), Jia et al.
patent: 6074626 (2000-06-01), Order
patent: 2003/0082102 (2003-05-01), Court
patent: WO 10/70755 (2001-09-01), None
S. Mirzadeh et al “Evaluation of Neutron Inelastic Scattering for Radioisotope Production,” App.Radia.Isot., 1997, Elsevier Science Ltd. (Great Britian) vol. 48, No. 4, p. 441-446.
Beets Arnold L.
Du Miting
Knapp, Jr. Furn F.
Mirzadeh Saed
Keith Jack
Marasco Joseph A.
UT-Battelle LLC
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