High quality, continuous throughput, tissue processing

Chemistry: molecular biology and microbiology – Apparatus – Differentiated tissue perfusion or preservation apparatus

Reexamination Certificate

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Reexamination Certificate

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07547538

ABSTRACT:
A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of nonaqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.

REFERENCES:
patent: 2150757 (1939-03-01), Bodine
patent: 2684925 (1954-07-01), Ferrari, Jr.
patent: 3389052 (1968-06-01), Ehrenreich et al.
patent: 3546334 (1970-12-01), Lerner et al.
patent: 3674040 (1972-07-01), Howells et al.
patent: 3892197 (1975-07-01), Kinney et al.
patent: 3961097 (1976-06-01), Gravlee, Jr.
patent: 3995022 (1976-11-01), Heanley et al.
patent: 4099483 (1978-07-01), Henderson
patent: 4141312 (1979-02-01), Louder et al.
patent: 4199558 (1980-04-01), Henderson
patent: 4221823 (1980-09-01), Pearson et al.
patent: 4300243 (1981-11-01), Baumgartner
patent: 4545831 (1985-10-01), Ornstein
patent: 4578282 (1986-03-01), Harrison
patent: 4656047 (1987-04-01), Kok et al.
patent: 4670386 (1987-06-01), Sugaar
patent: 4681996 (1987-07-01), Collins et al.
patent: 4734260 (1988-03-01), Lautenschlager
patent: 4784873 (1988-11-01), Kienecker et al.
patent: 4835354 (1989-05-01), Collins et al.
patent: 4839194 (1989-06-01), Malluche et al.
patent: 4857300 (1989-08-01), Maksem
patent: 4882128 (1989-11-01), Hukvari et al.
patent: 4891239 (1990-01-01), Dudley et al.
patent: 4911915 (1990-03-01), Fredenburgh
patent: 4992763 (1991-02-01), Bert et al.
patent: 5023187 (1991-06-01), Koebler et al.
patent: 5030929 (1991-07-01), Moeller
patent: 5049510 (1991-09-01), Repasi et al.
patent: 5068086 (1991-11-01), Sklenak et al.
patent: 5089288 (1992-02-01), Berger
patent: 5104640 (1992-04-01), Stokes
patent: 5122633 (1992-06-01), Moshammer et al.
patent: 5230865 (1993-07-01), Hargett et al.
patent: 5244787 (1993-09-01), Key et al.
patent: 5256571 (1993-10-01), Hürley et al.
patent: 5270010 (1993-12-01), Lautenschlager
patent: 5289140 (1994-02-01), Jorgenson et al.
patent: 5318795 (1994-06-01), Stokes et al.
patent: 5368820 (1994-11-01), Lautenschlager
patent: 5382414 (1995-01-01), Lautenschlager
patent: 5387397 (1995-02-01), Strauss et al.
patent: 5401625 (1995-03-01), Robinson
patent: 5408074 (1995-04-01), Warmbier et al.
patent: 5431952 (1995-07-01), Ocello
patent: 5432056 (1995-07-01), Hartman et al.
patent: 5447077 (1995-09-01), Lautenschlager
patent: 5460797 (1995-10-01), Ryan
patent: 5532462 (1996-07-01), Butwell et al.
patent: 5544650 (1996-08-01), Boon et al.
patent: 5625706 (1997-04-01), Lee et al.
patent: 5672696 (1997-09-01), Wang et al.
patent: 5679333 (1997-10-01), Dunphy
patent: 5712605 (1998-01-01), Flory et al.
patent: 5725835 (1998-03-01), Lautenschlager
patent: 5750008 (1998-05-01), Lautenschlager
patent: 5767493 (1998-06-01), Lautenschlager
patent: 5782897 (1998-07-01), Carr
patent: 5796080 (1998-08-01), Jennings et al.
patent: 5830417 (1998-11-01), Kingston
patent: 5849517 (1998-12-01), Ryan
patent: 5858178 (1999-01-01), Lautenschlager
patent: 5875286 (1999-02-01), Bernstein et al.
patent: 5939278 (1999-08-01), Boon et al.
patent: 5976829 (1999-11-01), Birnboim
patent: 5981924 (1999-11-01), Lautenschlager
patent: 6017725 (2000-01-01), Hoffmann et al.
patent: 6033912 (2000-03-01), Lautenschlager
patent: 6042874 (2000-03-01), Visinoni et al.
patent: 6054695 (2000-04-01), Lautenschlager
patent: 6072086 (2000-06-01), James et al.
patent: 6165723 (2000-12-01), Shah et al.
patent: 6183995 (2001-02-01), Burmer et al.
patent: 6204375 (2001-03-01), Lader
patent: 6207408 (2001-03-01), Essenfeld et al.
patent: 6242723 (2001-06-01), Lautenschlager
patent: 6248535 (2001-06-01), Danenberg et al.
patent: 6291180 (2001-09-01), Chu
patent: 6303005 (2001-10-01), Lautenschlager
patent: 6329645 (2001-12-01), Giberson et al.
patent: 6379921 (2002-04-01), Pajak
patent: 6451551 (2002-09-01), Zhan et al.
patent: 6455317 (2002-09-01), Lautenschlager
patent: 6458598 (2002-10-01), Huang
patent: 6531317 (2003-03-01), Guirguis et al.
patent: 6586713 (2003-07-01), Essenfeld et al.
patent: 6717119 (2004-04-01), Ondruschka et al.
patent: 6793890 (2004-09-01), Morales et al.
patent: 6797928 (2004-09-01), Giberson et al.
patent: 6913921 (2005-07-01), Fischer
patent: 6916608 (2005-07-01), Berger et al.
patent: 7070950 (2006-07-01), Song et al.
patent: 7075045 (2006-07-01), Visinoni
patent: 7273587 (2007-09-01), Birkner et al.
patent: 7273720 (2007-09-01), Birkner et al.
patent: 7297311 (2007-11-01), Tamura et al.
patent: 2001/0020599 (2001-09-01), Lautenschlager
patent: 2002/0084264 (2002-07-01), Ondruschka et al.
patent: 2002/0086346 (2002-07-01), Ryan
patent: 2002/0096340 (2002-07-01), Ondruschka et al.
patent: 2002/0176814 (2002-11-01), Lautenschlager et al.
patent: 2002/0177183 (2002-11-01), Giberson et al.
patent: 2003/0127311 (2003-07-01), Lautenschlager et al.
patent: 2003/0127313 (2003-07-01), Lautenschalger et al.
patent: 2003/0194352 (2003-10-01), Lautenschlager et al.
patent: 2004/0043504 (2004-03-01), Buhler et al.
patent: 2005/0034972 (2005-02-01), Lautenschlager
patent: 2005/0074422 (2005-04-01), Visinoni
patent: 2005/0090017 (2005-04-01), Morales
patent: 2007/0235448 (2007-10-01), Lihl et al.
patent: 2008/0078757 (2008-04-01), Lang et al.
patent: 19928820 (2000-12-01), None
patent: 0311035 (1989-04-01), None
patent: 0311035 (1989-04-01), None
patent: 0311035 (1990-01-01), None
patent: 0 562 877 (1993-09-01), None
patent: 0 680 243 (1995-04-01), None
patent: 0 849 582 (1997-11-01), None
patent: 822 403 (1998-02-01), None
patent: 1455174 (2004-09-01), None
patent: 1455174 (2004-12-01), None
patent: 1557722 (1979-12-01), None
patent: 3-14451 (1991-02-01), None
patent: 3-68865 (1991-03-01), None
patent: 3-68866 (1991-03-01), None
patent: 5-25347 (1993-04-01), None
patent: 5-149846 (1993-06-01), None
patent: WO 86/06479 (1986-11-01), None
patent: WO 98/05938 (1998-02-01), None
patent: WO 99/09390 (1999-02-01), None
Boon et al. “Microwave-stimulated diffusion for fast processing of tissue: Reduced dehydrating, clearing, and impregnating times” Histopathol. 10:303-309 (1986).
Boon et al. “Formaldehyde fixation and microwave irradiation” Histochem. 20:313-322 (1988).
Boon et al. “Microwave irradiation of human brain tissue: Production of microscopic slides within one day” J. Clin. Path. 41:590-593 (1988).
Kok et al. “Ultrarapid vacuum-microwave histoprocessing” Histochem. J. 27:411-419 (1995).
Kok et al. “Major improvement in microscopic-image quality of cryostat sections” Am. J. Pathol. 88:620-623 (1987).
Kok et al. “Physics of microwave technology in histochemistry” Histochem. J. 22:381-388 (1990).
Kok et al. “Microwaves for microscopy” J. Microscopy 158:291-322 (1990).
kok et al. “Histoprocessing with the microwave oven: An update” Histochem. J. 20:323-328 (1988).
Leong “Microwave fixation and rapid processing in a large througput histopathology laboratory” Pathology 23:271-273 (1991).
Leong et al. “Antigen preservation in microwave-irradiated tissues: A comparison with formaldehyde fixation” J. Pathol. 156:275-282 (1988).
Lewis et al. “Unlocking the archive—gene expression in paraffin-embedded tissue” J. Pathol. 195:66-71 (2001).
Morales et al. “Experience with an autmated microwave-assisted rapid tissue processing method” Am. J. Clin. Pathol. 121:528-536 (2004).
Rohr et al. “A comparison of routine and rapid microwave tissue processing in a surgical pathology laboratory” Am. J. Clin. Pathol. 115:703-708 (2001).
Romaguera et al. “Tools to facilitate and standardize grossing” Histologic 36:17-21 (2003).
Suurmeijer et al. “Note

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