High purity phthalein derivatives and method for preparing same

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S344000

Reexamination Certificate

active

07994215

ABSTRACT:
High purity phthalein derivatives are useful for medical applications and/or in the field of biotechnology. The phthalein derivatives are prepared by a method whereby a phthalic anhydride derivative is condensed with a naphthol or phenol derivative in an organic acid ester and the crystals of the resulting condensate are converted by action of a strong acid or one of its precursors in anhydrous medium.

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patent: 5637733 (1997-06-01), Sujeeth
patent: 6514700 (2003-02-01), Singh
patent: 136 498 (1979-11-01), None
patent: 360 691 (1992-10-01), None
R.C. Gibbs, “The Absorption Spectra of Some Phthaleins of the Trihydroxyphenols”J. Am. Chem. Soc. vol. 51 pp. 1755-1766 (1929).
Shawn C. Burdette et al., “Fluorescent Sensors for Zn2+ Based on a Fluorescein Platform: Synthesis, Properties and Intracellular Distribution”J. Am. Chem. Soc., vol. 123, pp. 7831-7841 (2001).
M.A. Matveets, et al., “Study of Spectrophotometric and Luminescence Properties of Hydroxyxanthene Dyes in Aqueous Solution”Zhumal Analiticheskoi Khimii, vol. 34, No. 6, pp. 1049-1054 (1979).
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US: XP002248842 accession No. STN Database accession No. 91:124850 abstract (1979).

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