Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-01-25
2009-12-01
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S341100
Reexamination Certificate
active
07625935
ABSTRACT:
One object of the invention is high purity butoconazole nitrate of the formula (I) (I) containing maximum 0.1 wt % of chemical impurities, wherein at least 95% of the particles of the substance are below 75 μm by diameter, whereas at least 99% of the particles are below 250 μm by diameter, and process for its preparation. A pharmaceutical composition comprising as active ingredient, high purity butoconazole nitrate of specified particle size in admixture with known auxiliaries is also within the scope of the invention.
REFERENCES:
Rostein, et al, abstract of “The synthesis and antifungal activity of the enantiomers of butoconazole nitrate,” Tetrahedron: Asymmetry. vol. 4 (Issue 7), Jul. 1993.
“1-[4-(4-Chlorophenyl)-2- . . . ” by Keith A.M. Walker et al. (Journal of Medicinal Chemistry, 1978, vol. 21, No. 8).
Bagdy Judit Nagyne
Czibula Laszlo
Dobay Laszlo
Papp Eva Werkne
Sebok Ferenc
Coppins Janet L.
Myers Jonathan
Richter Gedeon Vegyeszeti Gyar Rt.
Saeed Kamal A
Wilford Andrew
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