High purity albumin and method of producing

Details High purity albumin and method of producing High purity albumin and method of producing

1995-05-25

1998-03-17

Furman, Keith C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530363, 530364, 530413, 530414, 530416, 530417, C12N 1514, C07K 14765, B01J 4106, B01J 3906

Patent

active

057285535

ABSTRACT:
A process for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, fragments of albumin, polymers or aggregates of albumin, and viruses, and which is relatively non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises passing albumin (preferably expressed and secreted by transformed yeast) through two chromatography purifications, ultrafiltering the product, passing through two further chromatography steps and again ultrafiltering the product.

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