Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin
Patent
1997-11-14
2000-03-07
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Albumin
530363, 530364, 530413, 530414, 530416, 530417, 435 696, C07K 1400
Patent
active
060342218
ABSTRACT:
A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, fragments of albumin, polymers or aggregates of albumin, and viruses, and which is relatively non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises passing albumin (preferably expressed and secreted by transformed yeast) through two chromatography purifications, ultrafiltering the product, passing through two further chromatography steps and again ultrafiltering the product.
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Berezenko Stephen
Burton Steven J.
Coghlan David St. J.
Johnson Richard A.
Quirk Alan V.
Biswas Naomi S.
Delta Biotechnology Limited
Mohamed Abdel A.
Tsang Cecilia J.
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