Chemistry: analytical and immunological testing – Sulfur containing – Organic or sulfhydryl containing
Patent
1983-05-09
1986-01-21
Shaver, Paul F.
Chemistry: analytical and immunological testing
Sulfur containing
Organic or sulfhydryl containing
564 91, G01N 3300, C07C14378
Patent
active
045657874
ABSTRACT:
A method for the simultaneous detection, separation and analysis by reverse hase HPLC of sulfur mustard type compounds and their major hydrolysis and oxidation by-products utilizes a novel precolumn enhancement derivatization procedure. The method involves the reaction of these nonchromophoric sulfides with N-halogeno-N-metal arylsulfonamidates on a microscale to produce UV or visible absorbing or fluorescing arylsulfonylsulfilimine compounds. These arylsulfonylsulfilimine derivatives can then be readily separated on a low polarity C-18 column by reverse phase HPLC. The method permits quantitation of these sulfides by UV detector response in quantities as small as 20 nanograms.
REFERENCES:
patent: 3107229 (1963-10-01), Malz et al.
patent: 3542865 (1970-11-01), Bayer
patent: 4085093 (1978-04-01), Hopper
Bossle Paul C.
Martin John J.
Sarver Emory W.
Sommer Harold Z.
Costigan Edward F.
Gibson Robert P.
Lane Anthony T.
Shaver Paul F.
The United States of America as represented by the Secretary of
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