High performance chiral selector

Liquid purification or separation – With means to add treating material – Chromatography

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2105021, 210635, 210656, B01D 1508

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active

054220041

ABSTRACT:
A high performance chiral selector having the formula: ##STR1## wherein Ar is a monocyclic or ortho-fused polycyclic aromatic moiety having up to 10 ring carbon atoms, either of which may be unsubstituted or substituted with one or more C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, NO.sub.2, N(R.sub.5).sub.3.sup.+, CN, COOR.sub.6 SO.sub.3 H and COR.sub.7 groups wherein R.sub.5, R.sub.6 and R.sub.7 are each independently hydrogen or C.sub.1 to C.sub.6 alkyl;

REFERENCES:
patent: 4322310 (1982-03-01), House
patent: 4330440 (1982-05-01), Ayers
patent: 4512898 (1985-04-01), Oi
patent: 4565877 (1986-01-01), Wada
patent: 4604207 (1986-08-01), Oi
patent: 4627919 (1986-12-01), Yuki
patent: 4824950 (1989-04-01), Barcza
patent: 4830921 (1989-05-01), Kitayama
patent: 4909935 (1990-03-01), Bradshaw et al.
patent: 4919803 (1990-04-01), Doyle et al.
patent: 4963254 (1990-10-01), Oi
patent: 5051176 (1991-09-01), Miyano
patent: 5080795 (1992-01-01), Pirkle
patent: 5149426 (1992-09-01), Watabe
Aoyama, et al. (1986) "Photocyclization of N,N-Dialkyl-.beta.-.gamma.-Unsaturated Amides. 1,6-Hydrogen Transfer Via Charge-Transfer States", J. Chem. Soc. Perkin Trans. 1, 1165-1169.
Pirkle, et al. (1992) "Effect of Superfluous Remote Polar Functionally on Chiral Recognition", Journal of Chromatography 589, 45-51.
Pirkle, et al. (1984) "A Rational Approach to the Design of Highly Effective Chiral Stationary Phases for the Liquid Chromatographic Separation of Enantiomers", Journal of Pharmaceutical & Biomedical Analysis 2, 173-181.
Pirkle, et al. (1984) "A Chiral Stationary Phase for the Facile Resolution of Amino Acids, Amino Alcohols and Amines as the N-3, 5-Dinitrobenzoyl Derivatives", The Journal of Organic Chemistry 49, 3043-3046.
Pirkle, et al. (1984) "A Rational Approach to the Design of Highly-Effective Chiral Stationary Phases", Journal of Chromatography 316, 585-604.
Pirkle, et al. (1985) "Preparation and Use of Hydantoin-Based Chiral Stationary Phases", Journal of Chromatography 322, 309-320.
Pirkle, et al. (1986) "Separation of the Enantiomers of 3,5-Dinitrophenyl Carbamates and 3,5-Dinitropenyl Ureas", Journal of Liquid Chromatography 9, 443-453.
Hyun, et al. (1987) "Preparation an Evaluation of a Chiral Stationary Phase Bearing Both .pi.-Acidic and Basic Sites", Journal of Chromatography 393, 357-365.
Pirkle, et al. (1991) "Chromatographic Approach to the Measurement of the Interstrand Distance for Some Chiral Bonded Phases", Anal. Chem. 63, 16-20.
Pirkle, et al. (1991) "Chiral Stationary Phase Designed for .beta.-Blockers", Journal of Chromatography 557, 173-185.
Pirkle, et al. (1989) "Separation of the Enantiomers of N-Protected .alpha.-Amino Acids as Anilide and 3,5-Dimethylanilide Derivatives", Journal of Chromatography 478, 419-423.
Pirkle, et al. (1985) "Effect of Interstrand Distance Upon Chiral Recognition By A Chiral Stationary Phase", Journal of Chromatography 328, 1-9.
Pirkle, et al. (1981) "Chiral High-Pressure Liquid Chromatographic Stationary Phases. 4. Separation of the Enantiomers of Bi-.beta.-Napthols and Analogues", J. Org. Chem. 46, 4988-4991.
Wainer, et al. (1984) "Application of High-Performance Liquid Chromatographic Chiral Stationary Phases to Pharmaceutical Analysis: Structural and Conformation . . . Agents", Journal of Chromatography 284, 117-124.
Doyle, et al. (1985) "The Resolution of Enantiomeric Drugs Using HPLC Chiral Stationary Phases", Pharmaceutical Technology, 28, 30-32.
Wainer, et al. (1984) "The Application of HPLC Chiral Stationary Phases to Pharmaceutical Analysis: The Resolution of Some Tropic Acid Derivatives", Journal of Liquid Chromatography 7, 731-741.
Perry, et al., "Chiral Separations by HPLC. Theory and Practice: Developments With the Pirkle Covalent HPLC Column", No. 939 (undated), p. 1.
Wainer, et al. "Use of Chiral Stationary Phases to Resolve Molecules of Pharmacological Interest", Liquid Chromatography 2, 88-89, 97-98, 1984.
Bojarski (1989) "Chromatography of Enantiomers of 2-Arylpropionic Acids", Journal of Liquid Chromatography 12, 2685-2706.
Pirkle, et al. (1990) "The Separation of the Enantiomers of A Variety of Non-Steroidal Anti-Inflammatory Drugs (NSaids) As Their Anilide Derivatives Using A Chiral Stationary Phase", Journal of Liquid Chromatography 13, 2123-2134.
Pirkle, et al. (1989) "Improved Chiral Stationary Phase for the Separation of the Enantiomers of Chiral Acids as Their Anilide Derivatives", Journal of Chromatography 471, 271-281.
Pirkle, et al., (1989) "Use of Achiral Ion-Pairing Reagents with Chiral Stationary Phases", Journal of Chromatography 479, 377-386.
Pirkle, et al. (1991) "A Chiral Stationary Phase Which Affords Unusually High Levels of Enantioselectivity", Chirality 3, 183-187.
Pirkle, et al. (1988) "An Improved Chiral Stationary Phase for the Facile Separation of Enantiomers", Journal of Chromatography 441, 311-322.
Pirkle, et al. (1988) "Systematic Studies of Chiral Recognition Mechanisms", Plenum Press, 23-35.
Crossland, et al. (1970) "A Facile Synthesis of Methanesulfonate Esters", J. Org. Chem. 35, 3195-3196.
Pirkle, et al. (1986) "Intermolecular .sup.1 H[.sup.1 H]Nuclear Overhauser Effects in Diastereomeric Complexes: Support for a Chromatographically Derived Chiral Recognition Model", J. Am. Chem. Soc. 108, 5627-5628.
Prikle, et al. (1987) "Reciprocity in Chiral Recognition Comparison of Several Chiral Stationary Phases", Journal of Chromatography 404, 107-115.
Pirkle, et al. (1987) "Section 5, Products for Chromatographic Chiral Separations, Regis Advance Pirkle-Concept Technology", Regis, 42-54.
A copy of the Search Report of PCT/US93/05933 dated Oct. 14, 1993 pp. 1-6.
An Abstract of Japan Patent No. 60-66162 dated Apr. 16, 1985.

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