Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1993-03-16
1996-08-27
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
435851, 530350, A61K 39102, A61K 3816
Patent
active
055498973
ABSTRACT:
High molecular weight surface proteins of non-typeable Haemophilus influenzae which exhibit immunogenic properties and genes encoding the same are described. Specifically, genes coding for two immunodominant high molecular weight proteins, HMW1 and HMW2, have been cloned, expressed and sequenced, while genes coding for high molecular proteins HMW3 and HMW4 have been cloned, expressed and partially sequenced.
REFERENCES:
Barenkamp S. J., Pediatr Res 29(4 part 2) 1991 p. 167A Abstract #985.
Van Regenmortel, Immunology Today 10(8):266-272, 1989.
Dick et al, Contrib Microbiol. Immunol 10:48-114, 1989.
Roitt et al, eds Immunology, C. V. Mosby Co, St. Louis, Gowe-Medical Publishing, London, 1985 pp. 8.3-8.4.
Boslego et al Vaccine 9:154-162, 1991.
Pediatr. Infect. Dis. J., 9:333-339, 1990.
The Journal of Infectious Diseases, vol. 165(Suppl.), issued Aug. 1992, S. J. Barenkamp, "Outer Membrane Protein and Lipopolysaccharides of Nontypeable Haemophilus influenzae", pp. S181-S184, see entire document.
Infection and Immunity, vol. 56(1), issued Jan. 1988, E. J. Hansen, "Immune Enhancement of Pulmonary Clearance on Nontypable Haemophilus influenzae,"pp. 182-190, see entire document, especially Figs. 3 and 4.
Infection and Immunity, vol. 60(4), issued Apr. 1992, S. J. Barenkamp et al, "Cloning, Expression and DNA Sequence Analysis of Genes Encoding Nontypeable Haemophilus influenzae High -Molecular-Weight Surface-Exposed Proteins Related to Filamentous Hemagglutinin of Bordetella pertussis," pp. 1302-1313, see entire document.
Infection and Immunity, vol. 52(2), issued May 1986, S. J. Barenkamp, "Protection by Serum Antibodies in Experimental Nontypable Haemphilus influenzae Otitis Media", pp. 572-578, see Figs. 1 and 2.
Proceedings of the National Academy of Sciences USA, vol. 80, issued Mar. 1983, R. A. Young et al, "Efficient Isolation of Genes by Using Antibody Probes, "pp. 1194-1198, see entire document.
Journal of Molecular Biology, vol. 157, issued 1982, J. Kyte et al, "A Simple Method for Displaying the Hydrophatic Character of a Protein", pp. 105-132, see entire document.
Proceedings of the National Academy of Sciences, vol. 78(6), issued Jun. 1981, T. P. Hopp et al, "Prediction of Protein Antigenic Determinants from Amino Acid Sequences", pp. 3824-3828, see entire document.
Infection and Immunity, vol. 45(3), issued Sep. 1984, R. Schneerson et al, "Serum Antibody Responses of Juvenile and Infant Rhesus Monkeys Injected with Haemophilus influenzae Type b and Pneumoccus Type 6A Capsular Polysaccharide-Protein Conjugates", pp. 582-591, see entire document.
Barenkamp Stephen J.
St. Geme, III Joseph W.
Housel James C.
Krsek-Staples Julie
St. Louis University
Washington University
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