High molecular weight meningococcal group C vaccine and method f

Details High molecular weight meningococcal group C vaccine and method f High molecular weight meningococcal group C vaccine and method f

1978-06-26

1980-11-25

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 1, 424 92, 424180, C08B 3700

Patent

active

042359945

ABSTRACT:
A vaccine against Group C meningococcal meningitis consisting of a polysaccharide of which at least 80% by weight has a molecular weight in excess of 1,000,000 daltons is prepared. The polysaccharide was isolated from Group C hexadecyl trimethylammonium bromide cell paste with 1.0M CaCl.sub.2 extraction and purified by phenol extraction, ultracentrifugation at 100,000 g. and ethanol fractionation (30%-45% v/v in ethanol).

REFERENCES:
Kuvakina et al.--Chem. Abst., vol. 81, (1974) p. 134, 317q.
Bhattacharjee et al.--Chem Abst., vol. 84, (1976) p. 134,003W.
Apicella--Chem. Abst., vol. 85, (1976) 92,038Z.

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