High molecular weight electrodialysis

Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge

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2041826, 2041831, 204301, B01D 6142

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active

054377749

ABSTRACT:
A charged first molecular species is separated from a second molecular species by selectively passing one of the species through a separation membrane under the influence of an electrical potential. The separated species is maintained within a dialysate stream by retention membrane (or an electrode surface) adjacent the separation membrane. In a first embodiment, the charged species migrates across the separation membrane under the influence of the electric field, while a neutral or oppositely-charged species is maintained within the aqueous media. In the second embodiment, the charged species is maintained with the load channel, while a neutral species is passed into the dialysate chamber under the influence of a differential pressure.

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Reed, P. (Oct. 1985) Genetic Engineering News, vol. 5, No. 9, p. 10 "Electrodialysis: Large Scale Processing of Protein Solutions".
Wenisch, E., et al. (1992) "Purification to Single Isoforms of a Secreted Epidermal Growth Factor Receptor in a Multi-compartment Electrolyzer with Isoelectric Membranes" Electrophoresis 13:668-673.

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