High methionine derivatives of .alpha.-hordothionin for pathogen

Details High methionine derivatives of .alpha.-hordothionin for pathogen High methionine derivatives of .alpha.-hordothionin for pathogen

1996-02-29

1997-12-30

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530324, A61K 3800

Patent

active

057030499

ABSTRACT:
Derivatives of .alpha.-hordothionin made by position-specific substitution with methionine residues provide methionine enrichment in plants while retaining the anti-pathogenic activity of the parent compound.

REFERENCES:
patent: 5258300 (1993-11-01), Glassman et al.
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Berry-Lowe, et al. "The Nucleotide Sequence, Expression, and Evolution of One Member of a Multigene Family Encoding the Small Subunit of Ribulose-1,5-Bisphosphate Carboxylase in Soybean" J. of Mol. and Applied Genetics; vol. 1; pp. 483-498; (1982).
Cashmore, "Nuclear Genes Encoding the Small Subunit of Ribulose-1,5-Bisphosphate Carboxylase"; An Agricultural Perspective; pp. 29-38; (1983).
Coruzzi, et al. "Nucleotide Sequences of Two Pea cDNA Clones Encoding the Small Subunit of Ribulosse 1,5-Bisphosphate Carboxylase and the Major Chlorophyll a/b-binding Thylakoid Polypeptide" J. Biological Chemistry; vol. 258(3): pp. 1399-1042; (1983).
Dunsmuir, et al. "The Major Chlorophyll a/b Binding Protein of Petunia is Composed of Several Polypeptides Encoded by a Number of Distinct Nuclear Genes"; vol. 2; pp. 285-300; (1983).
Florack et al., 24 Plant. Mol. Biol. 83-96 (1994).
Brummer et al., 219 Eur. J. Biochem. 425-433 (1994).
Rao et al., 7(12) Prot. Engineer. 1485-93 (1994).
Matthews et al., in Biochemistry. pp. 137-141, The Benjamin Cummings Publishing Company, Inc., NY (1990).

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