High lysine derivatives of .alpha.-hordothionin

Details High lysine derivatives of .alpha.-hordothionin High lysine derivatives of .alpha.-hordothionin

1997-04-10

1999-11-23

Smith, Lynette R. F.

Multicellular living organisms and unmodified parts thereof and

Plant, seedling, plant seed, or plant part, per se

Higher plant, seedling, plant seed, or plant part

800279, 530300, 530372, 536 236, 435410, 435419, 435468, 4353201, A01H 500, C12N 1529, C12N 1582, A01G 1300

Patent

active

059903899

ABSTRACT:
Derivatives of .alpha.-hordothionin made by position-specific substitution with lysine residues provide lysine enrichment while retaining the antifungal activity of the parent compound.

REFERENCES:
patent: 5703049 (1997-12-01), Rao
Altenbach S.B. et al., "Manipulation of Methionine-Rich Protein Genes in Plant Seeds", Trends in Biotechnology, vol. 8, No. 6, 1990 pp. 156-160.
Altenbach S.B. et al., "Accumulation of a Brazil Nut Albumin in Seed of Transgenic Canola Results in Enhanced Levels of Seed Protein Methionine", Plant Molecular Biology, 18: 235-245, 1992 pp. 235-245.
Anderson J. et al., "A Transgenic Corn Line with Altered Levels of a High-Methionine Storage Protein", J. Cell Biochem Suppl., vol. 16F, p. 225, 1992, abstract.
Beach, L.R. et al., "Enchancing the nutritional value of Seed Crops", Current Top. Plant Physiol.: Biosynthesis & Molecular Regulation of Amino Acids in Plants, vol. 7, 1992 pp. 229-238.
Florack, D.E.A et al. "Expression of biologically active hordothionin in tobacco, Effects of pre- and pro- sequences at the amino and carboxyl termini of the hordothionin precursor on mature protein expression and sorting", Plant Molecular Biology vol. 24 1994, pp. 83-96.
Garcia-Olmeda, F. et al. "Trypsin/alpha-amylase inhibitors and thionins from cereals: possible role in crop protection", Journal of Exp. Botany Supplement, vol. 42, No. 238, May 1991 p. 4 and abstract p. 1. 5.
Karachi H. et al., "Seed Specific Expression of a Bacterial Desensitized Aspartate Kinase Increases the Production of Seed Threonine and Methionine in Transgenic Tobacco", The Plant Journal, vol. 3, No. 5, pp. 721-727, 1993.
Karachi H. et al., "Lysine synthesis and catabolism are coordinately regulated during tobacco seed development" PNAS 91, 1994 pp. 2577-2581, p. 2581 left column, last line right column.
Maddox, J. et al. "Cloning of a barley gene alpha-hordothionin, and expression in transgenic tobacco" J. Cell Biochem. Suppl. vol. 16F 1992 p. 217 and abstract p. 212.
Rao A.G. et al., "Validation of the Structure-function properties of alpha-hordothionin and derivatives through protein modeling"-see abstract; Protein Engineering: Supplement, Advances in Gene Technology Protein Engineering and Beyond. Miami Winter symposium, Jan. 17-22, 1993 vol. 6, 1993.
Rao A.G. et al., "Structure-Function Validation of High Lysine Analogs of .alpha.-Hordothionin Designed by Protein Modeling", Protein Engineering, vol. 7, No. 12, pp. 1485-1493, Dec. 1994.
Florack et al. Synthetic hordothionin genes as tools for bacterial disease resostance breeding. In: Agricultural Biotechnology in Focus in the Netherlands, Dekkers et al, eds. Pudoc, The Netherlands. pp. 39-48, 1990.
Krebbers et al. Expression of modified Seed storage proteins in transgenic plants. In:Transgenic Plants. Hiatt, ed. Marcel Dekker, Inc., New York. pp. 37-60, 1992.
Ponz et al. Cloning and nucleotide sequence of a cDNA encoding the precursor of the barley toxin -hordothionin. Eur. J. Biochem. vol. 156, pp. 131-135, 1986.

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