Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1996-09-20
2000-09-05
Guzo, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 691, 435 696, 4352523, 435440, 435 914, 435 9141, 435325, 4353201, C12N 1511, C12P 1540, C12P 1934
Patent
active
061141488
ABSTRACT:
The invention features a synthetic gene encoding a protein normally expressed in a mammalian cell wherein at least one non-preferred or less preferred codon in the natural gene encoding the protein has been replaced by a preferred codon encoding the same amino acid.
REFERENCES:
patent: 4652639 (1987-03-01), Stabinsky
patent: 5082767 (1992-01-01), Hatfield et al.
patent: 5270171 (1993-12-01), Cercek et al.
patent: 5276268 (1994-01-01), Strauch et al.
patent: 5405776 (1995-04-01), Kotewicz et al.
patent: 5464774 (1995-11-01), Baird et al.
patent: 5786464 (1998-07-01), Seed
Chiu et al., "Engineered GFP as a Vital Reporter in Plants" Current Biology 6:325-330 (1996).
Haas et al., "Codon Usage Limitation in the Expression of HIV-1 Envelope Glycoprotein" Current Biology 6:315-324 (1996).
Haseloff et al., "GFP in Plants" Trends in Genetics 11:328-329 (1995).
Zolotukhin et al., "A "Humanized" Green Fluorescent Protein cDNA Adapted for High-Level Expression in Mammalian Cells" Journal of Virology 70:4646-4654 (1996).
Fortkamp et al., DNA 5:511-517 (1986).
Chou et al., AIDS Research and Human Retroviruses 8:1967-1976 (1992).
Rangwala et al., Gene 122:263-269 (1992).
Scorer et al., Gene 136:111-119 (1993).
Holler et al., Gene 136:323-328 (1993).
Bosch et al., Journal of Virology 68:7566-7569 (1994).
van Hemert et al., Journal of Molecular Evolution 41:132-140 (1995).
Cohen et al. (abstract), in Modern Approaches New Vaccines, 64 (1988).
Hernan et al., Biochemistry 31:8619-8628 (1992).
Williams et al., Nucleic Acids Research 16/22:10453-10467 (1988).
Inouye et al., FEBS Letters 341:277-280 (1994).
Coulombe and Skup, Gene 46:89-95 (1986).
Kamiya et al., Jpn. J. Cancer Res. 80:200-203 (1989).
McCarrey, Nucleic Acids Res. 18:949-955 (1990).
Grantham et al., Nature 319:727-728 (1986).
Kypr et al., Nature 327:20 (1987).
Sharp, Nature 324:114 (1986).
Newgard et al., Proc. Natl. Acad. Sci. USA 83:8132-8136 (1986).
Sharp et al., Nucleic Acids Res. 16:8207-8211 (1988).
Cochrane et al., J. of Virology 65 (10):5305-5314 (1991).
D'Agostino et al., Mol. And Cell. Biol. 12(3):1375-1386 (1992).
Feinberg et al., Cell 46:807-817 (1986).
Hammarskjold et al. J. of Virol. 63(5):1959-1966 (1989).
Nakamura et al., FEBS Letters 289(1):123-125 (1991).
Robinson et al., Nucl. Acids. Res. 12(17):6663-6671 (1984).
Zhang et al., Gene 105(1):61-72 (1991).
Zhang et al., J. of Protein Chem. 12(3):329-335 (1993).
Seetharam et al., "Mistranslation in IGF-1 During Over-Expression of the Protein in Escherichia Coli Using a Synthetic Gene Containing Low Frequency Codons," Biochem. Biophys. Res. Comm. 155:518-523 (1988).
Haas Jurgen
Seed Brian
Elbing Karen L.
Guzo David
Shuman Jon
The General Hospital Corporation
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