High ibuprofen content granulations

Details High ibuprofen content granulations High ibuprofen content granulations

1990-01-11

1992-04-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424464, 424486, 424501, 424499, 424493, 424494, 424497, 424 7836, 427213, A61K 920, A61K 4732, A61K 916, A61K 3119

Patent

active

051046482

ABSTRACT:
A granular pharmaceutical composition containing 85 to 99 percent ibuprofen, 0.9 to 15.0 percent binder, and 0.1 to 5.0 percent polyvinylpyrrolidone, wherein the polyvinylpyrrolidone forms a film with a portion of said binder to form agglomerates, is disclosed. Ibuprofen may be fluidized with a portion of the binder in a fluid bed apparatus and sprayed with an aqueous dispersion of polyvinylpyrrolidone and the remainder of the binder. This granulation may be subsequently blended with additional excipients and, optionally, additional active pharmaceutical ingredients for direct compression into tablets.

REFERENCES:
patent: 3108046 (1963-10-01), Harbit
patent: 4209513 (1980-06-01), Torode et al.
patent: 4609675 (1986-09-01), Franz
patent: 4661521 (1987-04-01), Salpekar et al.
patent: 4753801 (1988-06-01), Oren et al.
patent: 4757090 (1988-07-01), Salpekar et al.
patent: 4806359 (1989-02-01), Radebaugh et al.
patent: 4911921 (1990-03-01), Denton et al.
GAF Corp., "Tableting with Plasdone.RTM. Povidone USP", 1981.

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