Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1989-02-02
1990-03-27
Schofer, Joseph L.
Drug, bio-affecting and body treating compositions
Lymphokine
424 78, 424482, 424479, 424480, 424470, 514570, A61K 3174, A61K 3179, A61K 926, A61K 936
Patent
active
049119214
ABSTRACT:
A granular pharmaceutical composition containing 85 to 99 percent ibuprofen, 0.9 to 15.0 percent binder, and 0.1 to 5.0 percent polyvinylpyrrolidone, wherein the polyvinylpyrrolidone forms a film with a portion of said binder to form agglomerates, is disclosed. Ibuprofen may be fluidized with a portion of the binder in a fluid bed apparatus and sprayed with an aqueous dispersion of polyvinylpyrrolidone and the remainder of the binder. This granulation may be subsequently blended with additional excipients and, optionally, additional active pharmaceutical ingredients for direct compression into tablets.
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patent: 4209513 (1980-06-01), Torode et al.
patent: 4609675 (1986-09-01), Franz
patent: 4661521 (1987-04-01), Salpekar et al.
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patent: 4757090 (1988-07-01), Salepkar et al.
patent: 4806359 (1989-02-01), Radebaugh et al.
GAF Corp. "Tableting with Plasdone.RTM. Povidone USP" 1981.
Denton Larry E.
Salepkar Anil M.
Bonner Grace L.
Klostermann Roy J.
Mallinckrodt Inc.
Pili-Curtis Carmen
Schofer Joseph L.
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