Drug – bio-affecting and body treating compositions – Burn treatment
Patent
1999-03-18
2000-06-20
Woodward, Ana
Drug, bio-affecting and body treating compositions
Burn treatment
525424, 525426, 525430, 525431, 525474, 525487, 525417, C08F28300, C08L 7100
Patent
active
060775009
ABSTRACT:
Higher generation radially layered copolymeric dendrimers having a hydrophilic poly(amidoamine) or a hydrophilic poly(propyleneimine) interior and a hydrophobic organosilicon exterior are prepared by first reacting a hydrophilic dendrimer having --NH.sub.2 surface groups with an organosilicon compound, and then hydrosilating the resulting copolymeric dendrimer with another organosilicon compound in the presence of a noble metal catalyst. In an alternate embodiment, the radially layered copolymeric dendrimers are prepared by reacting a hydrophilic dendrimer having --NH.sub.2 surface groups directly with an organosilicon dendron or organosilicon hyperbranched polymer.
REFERENCES:
patent: 4568737 (1986-02-01), Tomalia
patent: 4713975 (1987-12-01), Tomalia
patent: 4737550 (1988-04-01), Tomalia
patent: 5387617 (1995-02-01), Hedstrand
patent: 5393795 (1995-02-01), Hedstrand
patent: 5393797 (1995-02-01), Hedstrand
patent: 5560929 (1996-10-01), Hedstrand
patent: 5739218 (1998-04-01), Dvornic
P.R. Dvornic and D.A. Tomalia, "Molecules That Grow Like Trees, Dendritic Polymers: The Fourth Major Class of Macromolecular Architecture", Science Spectra, No. 5, pp. 36-41, (1996).
P.R. Dvornic and D.A. Tomalia, "Dendritic Polymers, Divergent Syntesis (Starburst (R) Polyamidamine Dendrimers)", in "The Polymeric Materials Encyclopedia", J.C. Salamone, ED., CRC Press Inc., Boca Raton, vol. 3, pp. 1814-1830, (1996).
P.R. Dvornic and D.A. Tomalia, "Recent Advances in Dendritic Polymers", Current Opinion in Colloid and Interface Science, vol. 1, Issue 2, pp. 221-235.
P.R. Dvornic, "Some Recent Advances in the Silicon Containing Polymers", Materials Science Forum, vol. 214, pp. 131-138, (1996).
I. Gitsov, K. Wooley, C.J. Hawker, P.T. Ivanova and J.M. Frechet, Macromolecules, 26, pp. 5621-5627, (1993).
T.M. Chapman, G. Hillyer, E.J. Mahan and K.A. Shaffer, J. Amer. Chem. Soc., 116, pp. 1195-1196, (1994).
T.M. Chapman and E.J. Mahan, Polymer Preprints, 73, pp. 275-276, (1995).
E.J. Mahan and T.M. Chapman, Polymer Preprints, 37(2), p. 247, (1996).
K. Lorenz, R. Mulhaupt, H. Frey, U. Rapp and F.J. Mayer-Posner, Macromolecules, 28, pp. 6657-6661, (1995).
A.W. Adamson, Physical Chemistry of Surfaces, 4th Ed., John Wiley & Sons, New York, pp. 70-78, (1982).
W. Noll, H. Steinbach and C. Sucker, Prog. Colloid Polym. Sci., 55, pp. 131-141, (1971).
D.A. Tomalia, "Dendritic Molecules", Sci. Amer., 272, pp. 62-66, (1995).
P. R. Dvornic and D.A. Tomalia, Macromol. Symp., 88, p. 123, (1994).
D.A. Tomalia et. al., "Proceedings of the 1st SPSJ International Polymer Conference", Kyoto, Japan, p. 65, (1984).
L.J. Mathias and T.W. Carothers, in "Advances in Dendritic Macromolecules", G.R. Newkome, Ed., JAI Press Inc., Greenwich, p. 101, (1995).
E.A. Rebrov, A.M. Muzafarov, V.S. Papkov and A.A. Zdanov, Dokl. Akad. Nauk. SSSR, 309, p. 376, (1989).
A. Morikawa, M. Kakimoto and Y. Imai, Macromolecules, 24, p. 3469, (1991).
A.W. van der Maade and P.W.N.M. van Leeuwen, J. Chem. Soc., Chem. Commun., p. 1400, (1992).
J.B. Lambert, J.L. Pflug and C.L. Stern, Angew. Chem. Int. Ed. Engl., 34, p. 98, (1995).
A. Sekiguchi, M. Nanjo, C. Kabuto and H. Sakurai, J. Am. Chem. Soc., 117, p. 4195, (1995).
H. Suzuki, Y. Kimata and A. Kuriyama, Chem. Lett., p. 293, (1995).
M.C. Coen, K. Lorenz, J. Kressler, H. Frey and R. Mulhaupt, Macromolecules, 29, p. 8069, (1996).
D. Seyferth et. al., Organometallics, 13, p. 2682, (1994).
D. Seyferth et. al., Organometallics, 14, p. 5362, (1995).
J. Roovers et. al., Macromolecules, 26, p. 4324, (1993).
G.R. Newkome, C.N. Moorefield and F. Vogtle, "Dendritic Molecules", VCH Publishers, Weinheim, (1996).
D.A. Tomalia et. al., Polymer J., 17, p. 117, (1985).
S. Watanabe and S. Regen, J. Am. Chem. Soc., 116, p. 8855, (1994).
M.J. Michalczyk and K.G. Sharp, "29th Organosilicon Symposium", Evanston, Illinois, Mar. 22-23, 1996.
"Molecular Electronics: Biosensors and Biocomputers", F.T. Hong, Ed., Plenum, New York, (1989).
"Molecular Electronic Devices", F.L. Carter, Ed., Dekker, New York, vol. 1, (1982).
"Molecular Electronic Devices", F.L. Carter, Ed., Dekker, New York, vol. 2, (1987).
D.A. Tirrell et. al., Chem. Eng. News, 12/19, p. 40, (1994).
J. Zhang and J.S. Moore, J. Am. Chem. Soc., 116, p. 2655, (1994).
G.R. Desirajer, Angew. Chem., 107, p. 2541, (1995).
G.R. Desirajer, Angew. Chem Int. Ed. Engl., 34, p. 2311, (1995).
Dvornic et. al., "Preparation & Evaluation of Radially Layered PAMAMOS Dendrimers", Polym. Mater. Sci. Eng., vol. 77, pp. 67-68, (1997).
Dvornic et. al., "Surface Properties of Radially Layered PAMAMOS Dendrimers", Polym. Mater. Sci. Eng., vol. 77, pp. 93-94, (1997).
Dvornic, P.R.; de Leuze-Jallouli, A.M.; Owen, M.J.; Perz S.V., Polym. Preprints, 1998, 39(1), 473.
Hawker, C.J.; Frechet, J.M.J., J. Am. Chem. Soc., 1992, 114, 8405.
Tomalia, D.A.; Naylor, A.M.; Goddard III, W.A., Angew. Chem. Int. Ed. Engl., 1990, 29, 138.
Tomalia, D.A.; Durst, H.D., Topics Curr. Chem., 1993, 165, 193.
van der Made, A.W.; van Leeuwen, P.W.N.M.; deWilde, J.C.; Brandes, R.A.C., Adv. Mater., 1993, 5, 466.
Nanjo, M.; Sekiguchi, A., Organometallics, 1998, 17, 492.
Hawker, C.J.; Frechet, J.M.J., "Three-Dimensional Dendritic Macromolecules: Design, Synthesis and Properties", Chapter 8 in "New Methods of Polymer Synthesis", Ebdon, J.R.; Eastmond, G.C., Eds., Blackie Academic and Professional, London, UK, 1995, vol. 2, pp. 290-330.
deLeuze-Jallouli Agnes M.
Dvornic Petar R.
Owen Michael James
Perz Susan Victoria
De Cesare James L.
Dendritech Incorporated
Dow Corning Corporation
Woodward Ana
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