Liquid purification or separation – Filter – Material
Patent
1994-10-21
1997-07-01
Spear, Frank
Liquid purification or separation
Filter
Material
2105003, 264 41, B01D 7116
Patent
active
056434529
ABSTRACT:
Semipermeable membranes are disclosed for purifying aqueous biological fluids. The membranes are particularly suitable for purifying extracorporeal blood via hemodialysis. The membranes, preferably configured as hollow fibers, are made from a hydrophilic polymeric material, preferably cellulose acetate. Features of the membranes include an ultrafiltration coefficient (K.sub.uF) of about 15 to about 55 mL/hr/mmHg/m.sup.2 (thus termed "high-flux" type membranes), a urea mass transfer coefficient (K.sub.oV (urea)) of at least 38.times.10.sup.-3 cm/min, and a ratio of K.sub.oV (urea)/K.sub.uF of at least 2.5.times.10.sup.-3. Hollow fibers of such membranes suitable for hemodialysis have a lumen diameter of about 175 to about 210 .mu.m and a wall thickness of about 10 to about 35 .mu.m. According to disclosed methods for making the membranes, a melt comprising about 32 to about 40% w/w cellulose acetate, about 5 to about 10% w/w glycerine, and about 50 to about 67% w/w polyethylene glycol is extruded to make hollow fibers; the fibers are cooled, cold-stretched, water-leached, and replasticized using a glycerine solution.
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First Annual Progress Report: Research on Improved Hollow Fiber Artificial Kidney, NIH Contract No. NIH-NIAMDD/70-2302, Nov. 1, 1971.
Second Annual Progress Report: Research on Improved Hollow Kidney, NIH Contract No. NIH-NIAMDD/70-2302, Dec. 31, 1972.
Third Annual Progress Report: Studies on the Molecular Etiology of Uremia Using High Flux Cellulose Acetate Dialyzers, NIH Contract No. NIH-NIAMDD/70-2302, Aug. 15, 1973.
Final Report: Research on Improved Hollow-Fiber Artificial Kidney, NIH Contract No. NIH-NIAMDD/70-2302, Dec. 31, 1973.
Marketing Literature for DUO-FLUX.RTM. Cellulose Acetate Hemodialyzer, Althin CD Medical, Inc. (Date unknown, but believed to be before filing date of subject application).
Proceedings of Second Annual Contractors' Conference of the Artificial Kidney Program of the National Institute of Arthritis and Metabolic Diseases, Held Jan. 22-24, 1969, pp. 69-70.
Althin Anders
Elsen Raymond
Fernandez Ben
Ruzius Kees
Silva Lalith
Althin Medical, Inc.
Spear Frank
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