High fidelity detection of nucleic acid differences by...

Details High fidelity detection of nucleic acid differences by... High fidelity detection of nucleic acid differences by...

2007-07-17

2007-07-17

Martinell, James (Department: 1634)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024310

Reexamination Certificate

active

10405882

ABSTRACT:
Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.

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