High-encapsulation liposome processing method

Details High-encapsulation liposome processing method High-encapsulation liposome processing method

1986-09-18

1988-06-21

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

424 11, 424450, 4284022, 436829, A61K 942, A61K 952, B01J 1302

Patent

active

047524251

ABSTRACT:
A method of preparing a suspension of liposomes containing a water-soluble compound predominantly in liposome-encapsulated form. A solution of vesicle-forming lipids in a chlorofluorocarbon solvent is infused under selected conditions into an aqueous medium, with continual solvent removal. The lipid infusion and solvent removal steps are continued until a lipid concentration of at least about 150 .mu.m/ml is reached, at which point more than about half of the compound contained in the resultant liposome suspension is in encapsulated form.

REFERENCES:
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4394372 (1983-07-01), Taylor
patent: 4608211 (1986-08-01), Handjani et al.
The Merck Index, published by Merck & Co., Inc., Rahway, N.J., Eighth Edition, 1968, p. 875.
David Cafiso; Howard Petty and Harden McConnell, "Preparation of Unilamellar Lipid Vesicles at 37.degree. C. by Vaporization Methods" 0005-2736/81/0000-0000/$02.50 .COPYRGT.1981 Elsevier/North Holland, Biomedical Press, BBA Report, 4 pages.
Hugh Schieren, Steven Rudolph, Morris Finkelstein, Peter Coleman "Comparison of Large Unilamellar Vesicles Prepared by a Petroleum Ether Vaporization Method with Multilamellar Vesicles", Bio-Chimica et Biophysica Acta, 542 (1978), 137-153 Elsevier/North Holland Biomed Press.

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