Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi
Reexamination Certificate
2011-04-26
2011-04-26
Mondesi, Robert B (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Fungi
C435S254110, C435S134000, C435S189000, C435S193000, C536S023200
Reexamination Certificate
active
07932077
ABSTRACT:
Engineered strains of the oleaginous yeastYarrowia lipolyticacapable of producing greater than 25% eicosapentaenoic acid (EPA, an ω-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.
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Damude Howard Glenn
Gillies Peter John
Macool Daniel Joseph
Picataggio Stephen K.
Pollak Dana M. Walters
Chowdhury Iqbal H
E. I. Du Pont de Nemours and Company
Mondesi Robert B
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