High efficient delivery of a large therapeutic mass aerosol

Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid

Reexamination Certificate

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C424S489000, C424S499000, C424S046000, C514S002600, C514S012200, C514S013800

Reexamination Certificate

active

06858199

ABSTRACT:
A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.

REFERENCES:
patent: 4069819 (1978-01-01), Valentini et al.
patent: 4995385 (1991-02-01), Valentini et al.
patent: 5260306 (1993-11-01), Boardman et al.
patent: 5304125 (1994-04-01), Leith
patent: 5506203 (1996-04-01), Bäckström et al.
patent: 5518998 (1996-05-01), Bäckström et al.
patent: 5641510 (1997-06-01), Clark et al.
patent: 5642728 (1997-07-01), Andersson et al.
patent: 5795594 (1998-08-01), York et al.
patent: 5830853 (1998-11-01), Bäckstrom et al.
patent: 5851453 (1998-12-01), Hanna et al.
patent: 5855913 (1999-01-01), Hanes et al.
patent: 5874064 (1999-02-01), Edwards et al.
patent: 5985309 (1999-11-01), Edwards et al.
patent: 5993805 (1999-11-01), Sutton et al.
patent: 5997848 (1999-12-01), Patton et al.
patent: 6019968 (2000-02-01), Platz et al.
patent: 6051256 (2000-04-01), Platz et al.
patent: 6063138 (2000-05-01), Hanna et al.
patent: 6136295 (2000-10-01), Edwards et al.
patent: 6165463 (2000-12-01), Platz et al.
patent: RE37053 (2001-02-01), Hanes et al.
patent: 6284282 (2001-09-01), Maa et al.
patent: 6372258 (2002-04-01), Platz et al.
patent: 6423344 (2002-07-01), Platz et al.
patent: WO 9500127 (1995-01-01), None
patent: WO 9632096 (1996-10-01), None
patent: WO 9632149 (1996-10-01), None
patent: WO 9816205 (1998-04-01), None
patent: WO 9817257 (1998-04-01), None
patent: WO 9831346 (1998-07-01), None
patent: WO 9916419 (1999-04-01), None
patent: WO 9966903 (1999-12-01), None
patent: WO 0010541 (2000-03-01), None
patent: WO 0033811 (2000-06-01), None
patent: WO 0113893 (2001-03-01), None
patent: WO 0151030 (2001-07-01), None
Wolff, R.K, “Safety of Inhaled Proteins for Therapeutic Use,”Journal of Aerosol Medicine, 11(4) :197-219 (1998).
Cipolla, D., et al., “Bolus Administration of INS365: Studying the Feasibility of Delivering HIgh Dose Drugs Using the AERx Pulmonary Delivery System,”Respiratory Drug Delivery, VII:231-239 (2000).
Scheuch, G., et al., “Measuring in vivo deposition of large porous particles,Journal of Aerosol Medicine,” 12(2) :127, #138 (1999).
J.N. Pritchard, et al., “Use of In Vitro Particle Size Data to Predict Deposition and Effects of Inhaled Drugs,”International Conference on Aerosol Therapy, Italy, (1998, Dec. 2-5).
Wang, J., et al., “Inhalation of Estradiol for Sustained Systemic Delivery,”Journal of Aerosol Medicine, 12(1) :27-36 (1999).
Huang, C-H., et al., “Calorimetric and Molecular Mechanics Studies of the Thermotropic Phase Behavior of Membrane Phospholipids,”Biochim. Biophys. Acta., 1422:273-307 (1999).
Edwards, D.A., “The Macrotransport of Aerosol Particles in the Lung: Aerosol Deposition Phenomena,”J. Aerosol Sci., 26(2) :293-317 (1995).
Edwards, D.A., et al., “Large Porous Particles for Pulmonary Drug Delivery,”Science276:1868-71 (1997).
Anderson, S.D., et al., A New Method for Bronchial-Provocation Testing in Asthmatic Subjects Using a Dry Powder of Mannitol,Am. J. Respir. Crit. Care Med. 156:758-765 (1997).
Anderson, S.D., et al., The Effect of Inhaling a Dry Powder of Sodium Chloride on the Airways of Asthmatic Subjects,Eur. Respir. J. 10:2465-2476 (1997).
Ben-Jebria, A., et al., “Large Porous Particles for Sustained Protection from Carbachol-Induced Bronchoconstriction in Guinea Pigs,”Pharm. Res. 16(4) :555-561(1999).
U.S. patent application No. 09/665,252, by Raymond T. Bartus and Dwaine F. Emerich, filed Sep. 19, 2000, Attorney Docket No.: 2685.1009-000.
U.S. patent application No. 09/877,734, by Raymond T. Bartus and Dwaine F. Emerich, filed Jun. 8, 2001, Attorney Docket No.: 2685.1009-001.
U.S. patent application No. 09/382,959, by Richard P. Batycky, Michael M. Lipp and Ralph Niven, filed Aug. 25, 1999, Attorney Docket No.: 2685.1004-000.
U.S. patent application No. 09/835,302, by David A. Edwards, et al., filed Apr. 16, 2001, Attorney Docket No.: 00166.0109.US00.
U.S. patent application No. 09/878,146, by David A. Edwards, Richard P. Batycky and Lloyd Johnston, filed Jun. 8, 2001, Docket No.: 2685.2001-003.

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