High-efficiency wild-type-free AAV helper functions

Details High-efficiency wild-type-free AAV helper functions High-efficiency wild-type-free AAV helper functions

2008-06-20

2010-12-14

Ketter, James S (Department: 1636)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C435S325000, C435S320100

Reexamination Certificate

active

07851195

ABSTRACT:
The present invention provides methods and compositions for producing high titer, wild-type-free preparations of recombinant AAV (“rAAV”) virions. The compositions of the present invention include novel nucleic acids encoding AAV helper functions and AAV helper function vectors. The present invention also includes host cells transfected by the claimed nucleic acids, methods of using the claimed vectors, and rAAV virions produced by such methods.

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