High-efficiency wild-type-free AAV helper functions

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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Details

C435S091330, C435S069100, C435S325000, C536S023100

Reexamination Certificate

active

07037713

ABSTRACT:
The present invention provides methods and compositions for producing high titer, wild-type-free preparations of recombinant AAV (“rAAV”) virions. The compositions of the present invention include novel nucleic acids encoding AAV helper functions and AAV helper function vectors. The present invention also includes host cells transfected by the claimed nucleic acids, methods of using the claimed vectors, and rAAV virions produced by such methods.

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