Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1998-08-28
1999-12-14
Degen, Nancy
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
4353201, 536 2372, C12N 510, C12N 1535, C12N 1586
Patent
active
060016507
ABSTRACT:
The present invention provides methods and compositions for producing high titer, wild-type-free preparations of recombinant AAV ("rAAV") virions. The compositons of the present invention include novel nucleic acids encoding AAV helper functions and AAV helper function vectors. The present invention also includes host cells transfected by the claimed nucleic acids, methods of using the claimed vectors, and rAAV virions produced by such methods.
REFERENCES:
patent: 5436146 (1995-07-01), Shenk et al.
patent: 5753500 (1998-05-01), Shenk et al.
"The Use of Heterologous Promoters For Adeno-Associated Virus (AAV) Protein Expression in AAV Vector Production", Ogasawara et al., Microbiol. Immunol., 42(3), pp. 177-185, 1998.
"Role of Highly Regulated rep Gene Expression In Adeno-Associated Virus Vector Production", Li et al., Journal of Virology, vol. 71, No. 7, pp. 5236-5243, Jul. 1997.
"Helper Free Stocks of Recombinant Adeno-Associated Viruses: Normal Integration Does Not Require Viral Gene Expression", Samulski et al., Journal of Virology, vol. 63, No. 9, pp. 3822-3828, Sep. 1989.
Avigen, Inc.
Chahine Kenneth G.
Degen Nancy
Schwartzman Robert
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