High efficiency retroviral vector which contains genetically...

Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...

Reexamination Certificate

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C435S320100, C435S325000, C435S455000, C435S252300

Reexamination Certificate

active

07049143

ABSTRACT:
The present invention provides a safe and highly efficient retroviral vector derived from the MLV (murine leukemia virus) for use in gene therapy, which lacks viral coding sequences but contains the genetically engineered EF Iα non-coding sequence harboring splicing acceptor.

REFERENCES:
patent: 5693508 (1997-12-01), Chang
patent: 2000-0006334 (2000-01-01), None
patent: WO 00/00629 (2000-01-01), None
Anderson, Nature, 1998, vol. 392, pp. 25-30.
Kmeic, American Scientist, 1999, vol. 87, pp. 240-247.
Fox, Nature Biotechnology, 2000, vol. 18, pp. 143-144.
Mountain, TIBTECH, 2000, vol. 18, pp. 119-128.
Juengst, BMJ, 2003, vol. 326, pp. 1410-1411.
Brenner et al., Biochimica et Biophysica Acta, 2003, vol. 1640, pp. 1-24.
Marshall, Science, 2003, vol. 299, p. 320.
Bakker, A.C., et al., “Prevention of Murine Collagen-induced Arthritis in the Knee and Ipsilateral Paw by Local Expression of Human Interleukin-1 Receptor Antagonist Protein in the Knee,”Arth.&Rheum. 40:893-900, Lippincott, Williams & Wilkins (1997).
Byun, J., et al., “Analysis of the relative level of gene expression from different retroviral vectors used for gene therapy,”Gene. Ther. 3:780-788, Stockton Press (1996).
Deonarain, M.P., “Ligand-targeted receptor-mediated vectors for gene delivery,”Exp. Opin. Ther. Patents 8:53-69, Ashley Publications Ltd. (1998).
Eck, S.L. and Wilson, J.M., “Chapter 5. Gene-Based Therapy,” in: Goodman & Gilman's the Pharmacological Basis of Therapeutics, 9thEd., McGraw-Hill, New York, NY, pp. 77-101 (1996).
Evans, C.H., et al., “Clinical Trial to Assess the Safety, Feasibility, and Efficacy of Transferring a Potentially Anti-Arthritic Cytokine Gene to Human Joints with Rheumatoid Arthritis,”Human Gene Ther. 7:1261-1280, Mary Ann Liebert, Inc. (1996).
Górecki, D.C., “Prospects and problems of gene therapy: an update,”Expert Opin. Emerging Drugs 6:187-198, Ashley Publications Ltd. (Oct. 2001).
Kim, S.H., et al., “Construction of Retroviral Vectors with Improved Safety, Gene Expression, and Versatility,”J. Virol. 72:994-1004, American Society for Microbiology (1998).
Lee, J.T., et al., “Engineering the splice acceptor for improved gene expression and viral titer in an MLV-based retroviral vector,”Gene Ther. 11:94-99, Nature Publishing Group (Jan. 2004).
Nouvel, P., et al., “The Spread of a Replication-Competent MuLV Retroviral Vector Can Be Efficiently Blocked by Deletion Variants,”Virol. 204:180-189, Academic Press, Inc. (1994).
Pfeifer A. and Verma, I.M. “Chapter 13. Virus Vectors and Their Applications,” in:Goodman&Gilman's The Pharmacological Basis of Therapeutics, 9thEd., McGraw-Hill, New York, NY, pp. 353-355 (1996).
Robbins, P.D., et al., “Gene therapy for arthritis,”Gene Therapy 10:902-911, Nature Publishing Group (May 2003).
Verma, I.M. and Somia, N., “Gene therapy—promises, problems and prospects,”Nature 389:239-242, Nature Publishing Group (1997).
Yu, S.S., et al., “High efficiency retroviral vectors that contain no viral coding sequences,”Gene Ther. 7:797-804, Macmillian Publishers Ltd. (May 2000).

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