High efficiency packed column supercritical fluid chromatography

Details High efficiency packed column supercritical fluid chromatography High efficiency packed column supercritical fluid chromatography

1993-06-17

1994-06-21

Therkorn, Ernest G.

Liquid purification or separation

Processes

Chromatography

210659, 95 82, 95 86, B01D 1508

Patent

active

053226275

ABSTRACT:
A method and device are disclosed for performing supercritical fluid chromatography in packed columns of at least about 0.5 mm inside diameter. The column provides at least 50,000, preferably at least 100,000, theoretical plates with pressure drop across the column of at least 25 bar. The outlet pressure is controlled by the back pressure regulator. The column may comprise a plurality of individual columns in series. Separation is performed at a rate of at least 25 plates/min, preferably at least 100 plates/min.

REFERENCES:
patent: 4479380 (1987-06-01), Novotny et al.
Snyder, Introduction to Modern Liquid Chromatography, John Wiley & Sons, Inc., 1979, pp. 227, 228, and 238-240.
Schoenmakers et al., Trends in Anal. Chem., vol. 6, No. 1 (1987). pp. 10-17.
Supercritical Fluid Chromatography, Roger M. Smith, editor, Chapter 4, pp. 102-136, publish 1988 Royal Soc. Chem., London.
Schoenmakers, J. High Res. Chrom & Chrom. Commun. vol. 11, Mar. 1988 (pp. 278-282).
Graham et al., J. Chrom. Sci. vol. 18, Feb. 1980 pp. 75-84.
Gere, Anal. Chem. 54, 736-740 (1982).
Schwartz, LC-GC, vol. 5, No. 1 (1987) pp. 14-22.
Mourier et al., Chromatographia vol. 23, No. 1 Jan. 1987 (pp. 21-25).
Janssen et al., J. High Res. Chrom. vol. 14, Jul. 1991 (pp. 438-445).
Schoenmakers et al., Chromatographia vol. 24, 1987 (pp. 51-57).
Novotny et al., J. Chrom. 61 (1971) pp. 17-28.
Berger et al., Chromatographia vol. 30, No. 1/2, Jul. 1990, pp. 57-60.
Halaz et al., J. Chrom. 112 (1975) 37-60.
Kraak, et al. J. Chrom. 122 (1976) 147-158.
Dewaele, et al., J. of HRC&CC, vol. 3 (Jun. 1980) 273-276.
Journal of Chromatography vol 468, 1 Dec. 1989, pp. 127-144 T. Dean et al. `Some Practical Aspects of Column Design, Etc.`.
Analytical Chemistry vol. 60, No. 6, 15 Mar. 1988, pp. 529-535 H. Kalinoski et al. `Pressure Programmed Microbore Column Supercritical Fluid Chromatography, Etc.`.
Journal of High Resolution Chromatography & Chromatography Communications vol. 8, No. 12, 1 Dec. 1985, pp. 824-828 R. Christensen `On Line Multidimensional Chromatography, Etc.`.
Journal of Chromatography vol. 477, 1 Dec. 1989, pp. 169-183 H. Engelhardt et al. `High Performance Liquid Chromatographic Columns, Etc.`.

Affiliated with

Also associated with

Rating

High efficiency packed column supercritical fluid chromatography does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with High efficiency packed column supercritical fluid chromatography, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High efficiency packed column supercritical fluid chromatography will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2219064