High efficiency packed column supercritical fluid chromatography

Details High efficiency packed column supercritical fluid chromatography High efficiency packed column supercritical fluid chromatography

1993-06-17

1994-08-23

Therkorn, Ernest G.

Liquid purification or separation

With means to add treating material

Chromatography

96101, 96106, B01D 1508

Patent

active

053404769

ABSTRACT:
A method and device are disclosed for performing supercritical fluid chromatography in packed columns of at least about 0.5 mm inside diameter. The column provides at least 50,000, preferably at least 100,000, theoretical plates with pressure drop across the column of at least 25 bar. The outlet pressure is controlled by the back pressure regulator. The column may comprise a plurality of individual columns in series. Separation is performed at a rate of at least 25 plates/min, preferably at least 100 plates/min.

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