Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-09-19
1997-07-08
Kunz, Gary L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 71, C07H 106, C07H 2100
Patent
active
056462638
ABSTRACT:
Methods for separating target particles, from a test medium in which the particles are suspended. The method contemplates utilization of blocking or masking particles which block or mask unwanted biological debris which tends to interfere with formation of complexes by which the target particles can be isolated. After centrifugation, the masking particles create a barrier between unwanted debris and test medium containing the target particles which permits the particles to be manipulated or modified without removing them from the debris. In a preferred aspect, magnetic separation techniques are used. In this aspect, non-magnetic 0.04 micron carboxylated polystyrene blocking particles are employed.
REFERENCES:
patent: 3700555 (1972-10-01), Widmark et al.
patent: 3970518 (1976-07-01), Giaever
patent: 4018886 (1977-04-01), Giaever
patent: 4230685 (1980-10-01), Senyei et al.
patent: 4267234 (1981-05-01), Rembaum
patent: 4375407 (1983-03-01), Kronick
patent: 4452773 (1984-06-01), Molday
patent: 4508625 (1985-04-01), Graham
patent: 4554088 (1985-11-01), Whitehead et al.
patent: 4659678 (1987-04-01), Forrest et al.
patent: 4710472 (1987-12-01), Saur et al.
patent: 4738773 (1988-04-01), Muller-Ruchholtz et al.
patent: 4978610 (1990-12-01), Forrest et al.
patent: 4988618 (1991-01-01), Li et al.
patent: 5186827 (1993-02-01), Liberti et al.
patent: 5200084 (1993-04-01), Liberti et al.
R. R. Oder, IEEE Trans. Magnetics, 12 (1976) 428-435.
C. Owen and P. Liberti, Cell Separation: Methods and Selected Applications, vol. 4, Pretlow and Pretlow eds., Academic Press, New York (1987), pp. 254-275.
Immunoassays for Clinical Chemistry, pp. 147-162, Hunter et al., eds., Churchill Livingston, Edinborough (1983), pp. 147-162.
L. S. Hersh and S. Yaverbaum, Clin. Chim. Acta, "Magnetic Solid-Phase Radioimmunoassay," 63, pp. 69-72 (1975).
J. T. Kemshead and J. Ugelstad, Molecular and Cellular Biochemistry, "Magnetic separation techniques: their application to medicine," 67, pp. 11-18 (1985).
Product Information Sheet, Magnetic Particle Concentrator, DYNAL MPC 1, Product No. 12001, DYNAL, A.S., Oslo, Norway, 1991.
Product Information Sheet, BioMag Separators, Product Nos. 4101S, 4102S, and 4106S, Advanced Magnetics, Inc., Cambridge, Massachusetts (Received in 1991).
Product Information Sheet, Magic.TM., magnetic immunochemistry method, Corning (No Available Date).
Brisco Paula R. G.
Ekenberg Steven J.
Oaklander Anne Louise
Frenchick Grady J.
Kunz Gary L.
Promega Corporation
The Johns Hopkins University
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