High efficiency genetic modification method

Details High efficiency genetic modification method High efficiency genetic modification method

1998-08-11

2000-09-05

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435440, 435455, 435456, 4353723, C12Q 168, C12Q 170, C12N 1586

Patent

active

061141135

ABSTRACT:
A method is provided for producing a population of genetically modified T cells. In the method, an in vitro population of T cells is activated by contacting said population with a CD3 binding agent. Genetic modification is then carried out with the activated T cells by contacting the same with a suitable gene transfer vector.

REFERENCES:
Anderson. Human Gene Therapy. Nature. vol. 392. Supp. pp. 25-30, Apr. 30, 1998.
Verma et al. Gene Therapy--Promises, Problems and Prospects. Nature. vol. 389. pp. 239-242, Sep. 18, 1997.
Orkin et al. Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, Dec. 7, 1995.
AH-1 Rudoll et al., "High-Efficiency Retroviral Vector Mediated Gene Transfer into Human Peripheral Blood CD4.sup.+," Gene Therapy 3:695-705 (1996).

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