High-efficiency AA V helper functions

Details High-efficiency AA V helper functions High-efficiency AA V helper functions

1998-06-30

2000-02-22

Schwartzman, Robert A.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4353201, 435369, C12N 510, C12N 701, C12N 1586

Patent

active

060279311

ABSTRACT:
The present invention provides methods and compositions for producing high titer preparations of recombinant AAV ("rAAV") virions. The compositions of the present invention include AAV helper function systems and host cells. The present invention also includes methods of using AAV helper function vectors that effect the production of only small amounts of the long forms of Rep protein, and rAAV virions produced by such methods.

REFERENCES:
patent: 4797368 (1989-01-01), Carter et al.
patent: 5589377 (1996-12-01), Lebkowski et al.
patent: 5622856 (1997-04-01), Natsoulis
patent: 5658776 (1997-08-01), Flotte et al.
patent: 5693531 (1997-12-01), Chiorini et al.
"The Use of Heterologous Promoters For Adeno-Associated Virus (AAV) Protein Expression in AAV Vector Production", Ogasawara et al., Microbiol. Immunol., 42(3), pp. 177-185, 1998.
"Role For Highly Regulated rep Gene Expression In Adeno-Associated Virus Vector Production", Li et al., Journal of Virology, vol. 71, No. 7, pp. 5236-5243, Jul. 1997.
"Analysis of Recombinant Adeno-Associated Virus Packaging And Requirements For rep and cap Gene Products", Vincent et al., Journal of Virology, vol. 71, No. 3, pp. 1897-1905, Mar. 1997.

Affiliated with

Also associated with

Rating

High-efficiency AA V helper functions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with High-efficiency AA V helper functions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High-efficiency AA V helper functions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-519761