High drug load acid labile pharmaceutical composition

Details High drug load acid labile pharmaceutical composition High drug load acid labile pharmaceutical composition

2006-10-17

2006-10-17

Tran, S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S451000, C424S452000, C424S457000, C424S458000, C424S459000, C424S461000

Reexamination Certificate

active

07122207

ABSTRACT:
A high drug load spheronized beadlet is provided wherein said beadlet comprises about 80% to 100% by weight of an acid labile medicament, preferably didanosine, about 0% to about 10% by weight of a disintegrant, and about 0% to about 10% by weight of a binder selected from the group consisting of sodium carboxymethylcellulose, hydroxypropylmethylcellulose, potassium alginate, and partially pregelatinized corn starch. A high drug load pharmaceutical composition, comprising the beadlet, with an enteric coating disposed thereon, is also provided.

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