High dose liposomal aerosol formulations containing cyclosporin

Details High dose liposomal aerosol formulations containing cyclosporin High dose liposomal aerosol formulations containing cyclosporin

1996-10-16

1999-09-28

Bawa, Raj

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424450, A61K 912, A61K 9127

Patent

active

059583789

ABSTRACT:
The present invention provides a high dose pharmaceutical liposome aerosol composition comprising about 12-30 mg/ml of a pharmaceutical compound, and about 130-375 mg of a phospholipid/ml starting reservoir concentration. Specifically, the present invention is drawn to anti-inflammatory glucocorticoids, immunosuppressive compounds, anti-fungal compounds, antibiotic compounds, anti-viral compounds, and anti-cancer compounds delivered via a high dose liposome aerosol composition in a phospholipid. More specifically, the invention provides a high dose cyclosporin A liposome aerosol composition comprising up to about 30 mg/ml cyclosporin A in up to about 225 mg of a phospholipid/ml starting reservoir concentration. Also provided is a high dose budesonide-liposome aerosol composition comprising up to about 15 mg/ml budesonide in up to about 225 mg of a phospholipid/ml starting reservoir concentration.

REFERENCES:
Waldrep et al. (1993). Int. J. Pharmaceutics 97:205-212.
Manthous et al. (1994). Chest 106(2):560.
Fornhem, C. (1995). Dis. Abst. Int., vol. 57/02-C, p. 549.

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