High dose formulations

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules

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424489, 264 41, A61K 948

Patent

active

054550459

ABSTRACT:
Mycophenolate mofetil and mycophenolic acid can be conveniently manufactured into high dose oral formulations by the hot melt filling of a supercooled mycophenolate mofetil or mycophenolic acid liquid into a pharmaceutical dosage form. High dose oral pharmaceutical formulations and manufacturing methods therefor are disclosed.

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Ewart T. Cole, "Liquid-Filled Hard-Gelatin Capsules", Pharm. Technol. 13 (9), 124-140 (1989).
Howard, et al., "Drug Release From Thermosetting Fatty Vehicles Filled Into Hard Gelatin Capsules", Drug Dev. & Indust. Phar., 13(6), 1031-1045 (1987).
Thomas, et al., "The Use of Xylitol as a Carrier for Liquid-Filled Hard-Gelatin Capsules", Pharm. Technol. Int. 36-40, Oct. 1991.
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