High-concentration liposome processing method

Details High-concentration liposome processing method High-concentration liposome processing method

1986-09-18

1988-11-01

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 46, 424 11, 424450, 436829, A61K 952, A61K 966, A61K 3722, B01J 1302

Patent

active

047818719

ABSTRACT:
A method of preparing a concentrated liposome suspension having a lipid concentration of greater than about 250 .mu.m/ml and liposome sizes no greater than about 0.4 microns. A solution of vesicle-forming lipids in a chlorofluorocarbon solvent is injected under selected conditions into an aqueous medium, with continual solvent removal. During the lipid injection and solvent-removal steps, the liposomes formed in the aqueous medium are extruded through a membrane, to reduce liposome sizes to less than about 0.6 microns. The lipid injection, solvent removal, and extrusion steps are continued until a lipid concentration of at least about 150 .mu.m/ml is reached.

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patent: 4394372 (1983-07-01), Taylor
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patent: 4544545 (1985-10-01), Ryan et al.
patent: 4608211 (1986-08-01), Handjani et al.
patent: 4652257 (1987-03-01), Chang
The Merck Index, published by Merck & Co., Inc., Rahway, N.J., Eighth edition, 1968, p. 875.

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