High concentration homogenized collagen compositions

Details High concentration homogenized collagen compositions High concentration homogenized collagen compositions

1994-04-19

1995-06-27

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530356, C08L 8906, A61L 1500, A61F 200, A61B 1900

Patent

active

054280249

ABSTRACT:
High concentration collagen compositions having improved persistence when administered for soft tissue augmentation are prepared from both cross-linked and non-cross-linked collagen starting materials. Suspensions of the starting materials are subjected to vigorous mechanical disruption to reduce the average collagen fiber size to below a threshold level which enhances the injectability of the composition. Thus, both enhanced injectability and enhanced persistence may be achieved using the same formulations.

REFERENCES:
patent: 3949073 (1976-04-01), Daniels et al.
patent: 4424208 (1984-01-01), Wallace et al.
patent: 4582640 (1986-04-01), Smestad et al.
patent: 4803075 (1989-02-01), Wallace et al.
McPherson et al. (1988) J. Dermatol. Surg. Oncol. 14 (suppl 1) 7 Jul.

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