High-capacity affinity supports and methods for the preparation

Details High-capacity affinity supports and methods for the preparation High-capacity affinity supports and methods for the preparation

1992-07-27

1994-11-08

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530350, 5303871, 5303901, 5303905, 530405, 530412, 530810, 530811, 530812, 530813, 530814, 530815, 530816, 525 541, C07K 320, C07K 1708, C07K 1712, C08G 6391

Patent

active

053628594

ABSTRACT:
An affinity support having an improved capacity for binding target compounds. The support includes an immobilized modified ligand of increased molecular weight. The molecular weight of the ligand is increased via the action of condensation reagents or crosslinkers prior to immobilization. The affinity support is useful in affinity separations of proteins and other biomolecules from complex, biologically-derived fluids.

REFERENCES:
Weber and Bailon, "Application of receptor-affinity chromatography to bioaffinity purification", Journal of Chromatography 510: 59-69 (1990).
Narayanan et al., "Preparative affinity chromatography of proteins--Influence of the physical properties of the base matrix", Journal of Chromatography 503: 93-102 (1990).
Nakamura et al., "Tresyl-activated support for high-performance affinity chromatography", Journal of Chromatography 510: 101-113 (1990).
Comoglio et al., "Factors affecting the properties of insolubilized antibodies", Biochimica et Biophysica Acta 420: 246-257 (1976).
Tharaken et al., "Effect of feed flow-rate, antigen concentration and antibody density on immunoaffinity purification of coagulation factor IX", Journal of Chromatography 552: 153-162 (1990).

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