High-bioavailability particle coated with fungicide and polymer

Details High-bioavailability particle coated with fungicide and polymer High-bioavailability particle coated with fungicide and polymer

2008-01-01

2008-01-01

Hartley, Michael G. (Department: 1609)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S400000, C424S472000, C424S489000

Reexamination Certificate

active

07314641

ABSTRACT:
The present invention discloses a high-bioavailability particle coated with fungicide and polymer, which mainly comprises: (a) a coating layer including fungicide, a polymer, an acidic substance, talc, a bonding agent, ethanol and dichloromethane; (b) an anticoagulant layer including talc, hydroxypropyl methylcellulose (HPMC) and a plasticizer; and (c) a particulate core having a diameter ranging from 300 μm to 500 μm (30˜50 mesh). In the present invention, the talc is added to prevent the particulate cores from aggregating. In addition, the particulate cores are small-sized enough and the polymer and the acidic substance are added to the coating layer, so that solubility is increased and bioavailability is thus improved.

REFERENCES:
patent: 6673373 (2004-01-01), Lee et al.
patent: 376322 (1999-12-01), None

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