High affinity thiophene-based and furan-based kinase ligands

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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Details

C544S152000, C544S359000, C546S213000, C546S214000, C546S280400, C546S284700

Reexamination Certificate

active

07446195

ABSTRACT:
Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

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Voegtle F. et al., “Amide-Based Rotaxanes with Terephthal Furan, Thiopene and Sulfonamide Subunits”, Synthesis (1996), vol. 3, pp. 353-356. XP002412666.
International Search Report for International Application No. PCT/US2006/031973, mailed Jan. 10, 2007 (5pgs).

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